S33084

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 532619

CAS#: 273203-30-8

Description: S33084 is a novel, potent, selective, and competitive antagonist at dopamine D(3)-receptors.


Price and Availability

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S33084 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 532619
Name: S33084
CAS#: 273203-30-8
Chemical Formula: C29H29N3O2
Exact Mass: 451.226
Molecular Weight: 451.57
Elemental Analysis: C, 77.14; H, 6.47; N, 9.31; O, 7.09


Synonym: S33084; S 33084; S-33084.

IUPAC/Chemical Name: N-[4-[(3aR,9bS)-8-cyano-3,3a,4,9b-tetrahydro-1H-chromeno[3,4-c]pyrrol-2-yl]butyl]-4-phenylbenzamide

InChi Key: QQJHRQZZCNYDMX-VPUSJEBWSA-N

InChi Code: InChI=1S/C29H29N3O2/c30-17-21-8-13-28-26(16-21)27-19-32(18-25(27)20-34-28)15-5-4-14-31-29(33)24-11-9-23(10-12-24)22-6-2-1-3-7-22/h1-3,6-13,16,25,27H,4-5,14-15,18-20H2,(H,31,33)/t25-,27+/m1/s1

SMILES Code: O=C(NCCCCN1C[C@@](COC2=C3C=C(C#N)C=C2)([H])[C@]3([H])C1)C4=CC=C(C5=CC=CC=C5)C=C4


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Mela F, Millan MJ, Brocco M, Morari M. The selective D(3) receptor antagonist, S33084, improves parkinsonian-like motor dysfunction but does not affect L-DOPA-induced dyskinesia in 6-hydroxydopamine hemi-lesioned rats. Neuropharmacology. 2010 Feb;58(2):528-36. doi: 10.1016/j.neuropharm.2009.08.017. Epub 2009 Sep 4. PubMed PMID: 19733554.

2: Millan MJ, Dekeyne A, Rivet JM, Dubuffet T, Lavielle G, Brocco M. S33084, a novel, potent, selective, and competitive antagonist at dopamine D(3)-receptors: II. Functional and behavioral profile compared with GR218,231 and L741,626. J Pharmacol Exp Ther. 2000 Jun;293(3):1063-73. PubMed PMID: 10869411.

3: Millan MJ, Gobert A, Newman-Tancredi A, Lejeune F, Cussac D, Rivet JM, Audinot V, Dubuffet T, Lavielle G. S33084, a novel, potent, selective, and competitive antagonist at dopamine D(3)-receptors: I. Receptorial, electrophysiological and neurochemical profile compared with GR218,231 and L741,626. J Pharmacol Exp Ther. 2000 Jun;293(3):1048-62. PubMed PMID: 10869410.

4: Cussac D, Newman-Tancredi A, Sezgin L, Millan MJ. [3H]S33084: a novel, selective and potent radioligand at cloned, human dopamine D3 receptors. Naunyn Schmiedebergs Arch Pharmacol. 2000 May;361(5):569-72. PubMed PMID: 10832613.

5: Cussac D, Newman-Tancredi A, Sezgin L, Millan MJ. The novel antagonist, S33084, and GR218,231 interact selectively with cloned and native, rat dopamine D(3) receptors as compared with native, rat dopamine D(2) receptors. Eur J Pharmacol. 2000 Apr 7;394(1):47-50. PubMed PMID: 10771033.