JNJ-2408068

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530637

CAS#: 317846-22-3

Description: JNJ-2408068, also known as HE066500 and R170591, is an inhibitor of respiratory syncytial virus (RSV). JNJ-2408068 exhibited potent antiviral activity with 50% effective concentrations (EC50s) of 2.1 nM. A similar inhibitory effect was observed in a RSV-mediated cell fusion assay (EC50= 0.9 nM). JNJ-2408068 interferes with RSV fusion through a mechanism involving a similar interaction with the F protein.


Price and Availability

Size
Price

Size
Price

Size
Price

JNJ-2408068 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 530637
Name: JNJ-2408068
CAS#: 317846-22-3
Chemical Formula: C22H30N6O
Exact Mass: 394.2481
Molecular Weight: 394.523
Elemental Analysis: C, 66.98; H, 7.66; N, 21.30; O, 4.06


Synonym: R170591; R-170591; R 170591; HE066500; HE-066500; HE 066500; JNJ-2408068; JNJ 2408068; JNJ2408068.

IUPAC/Chemical Name: 2-[[2-[[1-(2-aminoethyl)piperidin-4-yl]amino]-4-methylbenzimidazol-1-yl]methyl]-6-methylpyridin-3-ol

InChi Key: RDQSNNMSDOHAPG-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H30N6O/c1-15-4-3-5-19-21(15)26-22(25-17-8-11-27(12-9-17)13-10-23)28(19)14-18-20(29)7-6-16(2)24-18/h3-7,17,29H,8-14,23H2,1-2H3,(H,25,26)

SMILES Code: OC1=CC=C(C)N=C1CN2C3=CC=CC(C)=C3N=C2NC4CCN(CCN)CC4


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Del Vecchio AM, Sarisky RT. Cold virus fusion or stopping fusion cold--inhibitors of the human respiratory syncytial virus F protein. Recent Pat Antiinfect Drug Discov. 2006 Jun;1(2):247-54. Review. PubMed PMID: 18221150.

2: Bonfanti JF, Doublet F, Fortin J, Lacrampe J, Guillemont J, Muller P, Queguiner L, Arnoult E, Gevers T, Janssens P, Szel H, Willebrords R, Timmerman P, Wuyts K, Janssens F, Sommen C, Wigerinck P, Andries K. Selection of a respiratory syncytial virus fusion inhibitor clinical candidate, part 1: improving the pharmacokinetic profile using the structure-property relationship. J Med Chem. 2007 Sep 20;50(19):4572-84. Epub 2007 Aug 28. PubMed PMID: 17722899.

3: Douglas JL, Panis ML, Ho E, Lin KY, Krawczyk SH, Grant DM, Cai R, Swaminathan S, Chen X, Cihlar T. Small molecules VP-14637 and JNJ-2408068 inhibit respiratory syncytial virus fusion by similar mechanisms. Antimicrob Agents Chemother. 2005 Jun;49(6):2460-6. PubMed PMID: 15917547; PubMed Central PMCID: PMC1140497.

4: Wyde PR, Chetty SN, Timmerman P, Gilbert BE, Andries K. Short duration aerosols of JNJ 2408068 (R170591) administered prophylactically or therapeutically protect cotton rats from experimental respiratory syncytial virus infection. Antiviral Res. 2003 Nov;60(3):221-31. PubMed PMID: 14638398.

5: Andries K, Moeremans M, Gevers T, Willebrords R, Sommen C, Lacrampe J, Janssens F, Wyde PR. Substituted benzimidazoles with nanomolar activity against respiratory syncytial virus. Antiviral Res. 2003 Nov;60(3):209-19. PubMed PMID: 14638397.