A-834735

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530626

CAS#: 895155-57-4

Description: A-834735 is a drug developed by Abbott Laboratories that acts as a potent cannabinoid receptor full agonist at both the CB1 and CB2 receptors, with a Ki of 12 nM at CB1 and 0.21 nM at CB2.


Price and Availability

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A-834735 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 530626
Name: A-834735
CAS#: 895155-57-4
Chemical Formula: C22H29NO2
Exact Mass: 339.2198
Molecular Weight: 339.479
Elemental Analysis: C, 77.84; H, 8.61; N, 4.13; O, 9.43


Synonym: A-834735; A 834735; A834735; A-834,735; A 834,735; A834,735.

IUPAC/Chemical Name: [1-[(tetrahydro-2H-pyran-4-yl)methyl]-1H-indol-3-yl](2,2,3,3-tetramethylcyclopropyl)-methanone

InChi Key: NQTMRZNYLIGQCF-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H29NO2/c1-21(2)20(22(21,3)4)19(24)17-14-23(13-15-9-11-25-12-10-15)18-8-6-5-7-16(17)18/h5-8,14-15,20H,9-13H2,1-4H3

SMILES Code: O=C(C1=CN(CC2CCOCC2)C3=C1C=CC=C3)C4C(C)(C)C4(C)C


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Byrska B, Stanaszek R, Zuba D. Alpha-PVP as an active component of herbal
highs in Poland between 2013 and 2015. Drug Test Anal. 2016 Dec 30. doi:
10.1002/dta.2151. [Epub ahead of print] PubMed PMID: 28035764.

2: Grim TW, Morales AJ, Gonek MM, Wiley JL, Thomas BF, Endres GW, Sim-Selley LJ,
Selley DE, Negus SS, Lichtman AH. Stratification of Cannabinoid 1 Receptor (CB1R)
Agonist Efficacy: Manipulation of CB1R Density through Use of Transgenic Mice
Reveals Congruence between In Vivo and In Vitro Assays. J Pharmacol Exp Ther.
2016 Nov;359(2):329-339. Epub 2016 Aug 17. PubMed PMID: 27535976; PubMed Central
PMCID: PMC5074482.