A-796260

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530624

CAS#: 895155-26-7

Description: A-796260 or A-796,260, also known as LTI-258, is a drug developed by Abbott Laboratories that acts as a potent and selective cannabinoid CB2 receptor agonist. A-796,260 was found to be a highly selective CB2 agonist with little affinity for CB1, having a CB2 Ki of 4.6 nM vs 945 nM at CB1. It has potent analgesic and anti-inflammatory actions in animal models, being especially effective in models of neuropathic pain, but without producing cannabis-like behavioral effects.


Price and Availability

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A-796260 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 530624
Name: A-796260
CAS#: 895155-26-7
Chemical Formula: C22H30N2O2
Exact Mass: 354.2307
Molecular Weight: 354.494
Elemental Analysis: C, 74.54; H, 8.53; N, 7.90; O, 9.03


Synonym: A-796260; A 796260; A796260; A-796,260; A 796,260; A79,6260; LTI-258; LTI 258; LTI258.

IUPAC/Chemical Name: [1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](2,2,3,3-tetramethylcyclopropyl)-methanone

InChi Key: ZCFHOMLAFTWDFM-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H30N2O2/c1-21(2)20(22(21,3)4)19(25)17-15-24(18-8-6-5-7-16(17)18)10-9-23-11-13-26-14-12-23/h5-8,15,20H,9-14H2,1-4H3

SMILES Code: O=C(C1=CN(CCN2CCOCC2)C3=C1C=CC=C3)C4C(C)(C)C4(C)C


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Yao BB, Hsieh GC, Frost JM, Fan Y, Garrison TR, Daza AV, Grayson GK, Zhu CZ,
Pai M, Chandran P, Salyers AK, Wensink EJ, Honore P, Sullivan JP, Dart MJ, Meyer
MD. In vitro and in vivo characterization of A-796260: a selective cannabinoid
CB2 receptor agonist exhibiting analgesic activity in rodent pain models. Br J
Pharmacol. 2008 Jan;153(2):390-401. Epub 2007 Nov 12. PubMed PMID: 17994110;
PubMed Central PMCID: PMC2219533.