WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 530624
Description: A-796260 or A-796,260, also known as LTI-258, is a drug developed by Abbott Laboratories that acts as a potent and selective cannabinoid CB2 receptor agonist. A-796,260 was found to be a highly selective CB2 agonist with little affinity for CB1, having a CB2 Ki of 4.6 nM vs 945 nM at CB1. It has potent analgesic and anti-inflammatory actions in animal models, being especially effective in models of neuropathic pain, but without producing cannabis-like behavioral effects.
MedKoo Cat#: 530624
Chemical Formula: C22H30N2O2
Exact Mass: 354.2307
Molecular Weight: 354.494
Elemental Analysis: C, 74.54; H, 8.53; N, 7.90; O, 9.03
Synonym: A-796260; A 796260; A796260; A-796,260; A 796,260; A79,6260; LTI-258; LTI 258; LTI258.
IUPAC/Chemical Name: [1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](2,2,3,3-tetramethylcyclopropyl)-methanone
InChi Key: ZCFHOMLAFTWDFM-UHFFFAOYSA-N
InChi Code: InChI=1S/C22H30N2O2/c1-21(2)20(22(21,3)4)19(25)17-15-24(18-8-6-5-7-16(17)18)10-9-23-11-13-26-14-12-23/h5-8,15,20H,9-14H2,1-4H3
SMILES Code: O=C(C1=CN(CCN2CCOCC2)C3=C1C=CC=C3)C4C(C)(C)C4(C)C
1: Yao BB, Hsieh GC, Frost JM, Fan Y, Garrison TR, Daza AV, Grayson GK, Zhu CZ,
Pai M, Chandran P, Salyers AK, Wensink EJ, Honore P, Sullivan JP, Dart MJ, Meyer
MD. In vitro and in vivo characterization of A-796260: a selective cannabinoid
CB2 receptor agonist exhibiting analgesic activity in rodent pain models. Br J
Pharmacol. 2008 Jan;153(2):390-401. Epub 2007 Nov 12. PubMed PMID: 17994110;
PubMed Central PMCID: PMC2219533.