HBF-0259

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530621

CAS#: 957011-15-3

Description: HBF-0259 is a novel inhibitors of hepatitis B virus surface antigen (HBsAg) secretion. HBF-0259 was identified to inhibit HBsAg with an EC50 of 11.3 μM and a CC50 value of >50 μM in HepG2.2.15 cells. HBF-0259 had a 50% effective concentration of approximately 1.5 microM in a secondary, HBV-expressing cell line, with a concentration that exhibited 50% cytotoxicity of >50 microM. The equilibrium concentration of HBF-0259 in aqueous solution at physiological pH was 15 to 16 microM; the selective index was thus >9.


Price and Availability

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HBF-0259 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 530621
Name: HBF-0259
CAS#: 957011-15-3
Chemical Formula: C16H12Cl2FN5
Exact Mass: 363.0454
Molecular Weight: 364.2054
Elemental Analysis: C, 52.77; H, 3.32; Cl, 19.47; F, 5.22; N, 19.23


Synonym: HBF-0259; HBF 0259; HBF0259.

IUPAC/Chemical Name: 7-(2-Chloro-6-fluorophenyl)-5-(4-chlorophenyl)-1,5,6,7-tetrahydrotetrazolo[1,5-a]pyrimidine

InChi Key: BRBZPYDLUUWBCD-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H12Cl2FN5/c17-10-6-4-9(5-7-10)13-8-14(24-16(20-13)21-22-23-24)15-11(18)2-1-3-12(15)19/h1-7,13-14H,8H2,(H,20,21,23)

SMILES Code: ClC1=CC=C(C2N=C3N(NN=N3)C(C4=C(F)C=CC=C4Cl)C2)C=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

The high levels of hepatitis B virus (HBV) surface antigen (HBsAg)-bearing subviral particles in the serum of chronically infected individuals play an important role in suppressing HBV-specific immune response and are only mildly affected by the current small molecule therapies.


References

1: Yu W, Goddard C, Clearfield E, Mills C, Xiao T, Guo H, Morrey JD, Motter NE,
Zhao K, Block TM, Cuconati A, Xu X. Design, synthesis, and biological evaluation
of triazolo-pyrimidine derivatives as novel inhibitors of hepatitis B virus
surface antigen (HBsAg) secretion. J Med Chem. 2011 Aug 25;54(16):5660-70. doi:
10.1021/jm200696v. Epub 2011 Aug 2. PubMed PMID: 21786803; PubMed Central PMCID:
PMC3158247.

2: Dougherty AM, Guo H, Westby G, Liu Y, Simsek E, Guo JT, Mehta A, Norton P, Gu
B, Block T, Cuconati A. A substituted tetrahydro-tetrazolo-pyrimidine is a
specific and novel inhibitor of hepatitis B virus surface antigen secretion.
Antimicrob Agents Chemother. 2007 Dec;51(12):4427-37. Epub 2007 Sep 17. PubMed
PMID: 17875990; PubMed Central PMCID: PMC2167973.