Ro01-6128
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 532546

CAS#: 302841-86-7

Description: Ro01-6128 is a positive allosteric modulator of mGlu1 receptors. Ro01-6128 potentiates glutamate-induced calcium release (EC50 = 104.2 nM at rat mGluR1a).

Chemical Structure

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Ro01-6128
CAS# 302841-86-7
Instruction

Theoretical Analysis

MedKoo Cat#: 532546
Name: Ro01-6128
CAS#: 302841-86-7
Chemical Formula: C17H17NO3
Exact Mass: 283.12
Molecular Weight: 283.330
Elemental Analysis: C, 72.07; H, 6.05; N, 4.94; O, 16.94

Price and Availability

Size Price Availability Quantity
10mg USD 285 2 Weeks
50mg USD 850 2 Weeks
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Synonym: Ro01-6128; Ro-01-6128; Ro 01-6128.

IUPAC/Chemical Name: ethyl N-[2,2-di(phenyl)acetyl]carbamate

InChi Key: ILSZPWZFQHSKLW-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H17NO3/c1-2-21-17(20)18-16(19)15(13-9-5-3-6-10-13)14-11-7-4-8-12-14/h3-12,15H,2H2,1H3,(H,18,19,20)

SMILES Code: O=C(OCC)NC(C(C1=CC=CC=C1)C2=CC=CC=C2)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 283.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Brock et al (2007) Activation of a dimeric metabotropic glutamate receptor by intersubunit rearrangement. J.Biol.Chem. 282 33000. PMID: 17855348.

2. Hemstapat et al (2006) A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators. Mol.Pharmacol. 70 616. PMID: 16645124.