R214127

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 532488

CAS#: 409345-76-2

Description: R214127 is a novel high-affinity radioligand for the mGlu1 receptor.


Price and Availability

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Price

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R214127 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 532488
Name: R214127
CAS#: 409345-76-2
Chemical Formula: C20H17NO2
Exact Mass: 303.1259
Molecular Weight: 303.36
Elemental Analysis: C, 79.19; H, 5.65; N, 4.62; O, 10.55


Synonym: R214127; R 214127; R-214127.

IUPAC/Chemical Name: 1-(3,4-dihydro-2H-pyrano[2,3-b]quinolin-7-yl)-2-phenylethanone

InChi Key: HXUSRWUBSYSWII-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H17NO2/c22-19(11-14-5-2-1-3-6-14)15-8-9-18-17(12-15)13-16-7-4-10-23-20(16)21-18/h1-3,5-6,8-9,12-13H,4,7,10-11H2

SMILES Code: O=C(C1=CC=C2N=C3C(CCCO3)=CC2=C1)CC4=CC=CC=C4


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Simon L, Toth J, Molnar L, Agoston DV. MRI analysis of mGluR5 and mGluR1 antagonists, MTEP and R214127 in the cerebral forebrain of awake, conscious rats. Neurosci Lett. 2011 Nov 14;505(2):155-9. doi: 10.1016/j.neulet.2011.10.010. Epub 2011 Oct 12. PubMed PMID: 22015763.

2: Lavreysen H, Pereira SN, Leysen JE, Langlois X, Lesage AS. Metabotropic glutamate 1 receptor distribution and occupancy in the rat brain: a quantitative autoradiographic study using [3H]R214127. Neuropharmacology. 2004 Apr;46(5):609-19. PubMed PMID: 14996538.

3: Lavreysen H, Janssen C, Bischoff F, Langlois X, Leysen JE, Lesage AS. [3H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonists. Mol Pharmacol. 2003 May;63(5):1082-93. PubMed PMID: 12695537.