HBX-41108
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407460

CAS#: 924296-39-9

Description: HBX 41108 is an inhibitor of ubiquitin-specific protease (USP) 7. HBX 41108 inhibits USP7 deubiquitinating activity with an IC(50) in the submicromolar range. HBX 41,108 was shown to affect USP7-mediated p53 deubiquitination in vitro and in cells. As RNA interference-mediated USP7 silencing in cancer cells, HBX 41,108 treatment stabilized p53, activated the transcription of a p53 target gene without inducing genotoxic stress, and inhibited cancer cell growth. HBX 41,108 induced p53-dependent apoptosis as shown in p53 wild-type and null isogenic cancer cell lines.


Price and Availability

Size
Price

1g
USD 3650
Size
Price

2g
USD 4650
Size
Price

5g
USD 6950

HBX 41108 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 407460
Name: HBX-41108
CAS#: 924296-39-9
Chemical Formula: C13H3ClN4O
Exact Mass: 265.9995
Molecular Weight: 266.644
Elemental Analysis: C, 58.56; H, 1.13; Cl, 13.29; N, 21.01; O, 6.00


Related CAS #:  

Synonym: HBX 41108; HBX-41108; HBX41108; HBX 41,108; HBX-41,108; HBX41,108.

IUPAC/Chemical Name: 7-Chloro-9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile

InChi Key: BIGPXXAUSQLTQR-UHFFFAOYSA-N

InChi Code: InChI=1S/C13H3ClN4O/c14-6-1-2-7-8(3-6)13(19)12-11(7)17-9(4-15)10(5-16)18-12/h1-3H

SMILES Code: N#CC1=C(C#N)N=C2C(C(C3=C2C=CC(Cl)=C3)=O)=N1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Nicholson B, Suresh Kumar KG. The multifaceted roles of USP7: new therapeutic
opportunities. Cell Biochem Biophys. 2011 Jun;60(1-2):61-8. doi:
10.1007/s12013-011-9185-5. Review. PubMed PMID: 21468693.

2: Colland F, Formstecher E, Jacq X, Reverdy C, Planquette C, Conrath S, Trouplin
V, Bianchi J, Aushev VN, Camonis J, Calabrese A, Borg-Capra C, Sippl W, Collura
V, Boissy G, Rain JC, Guedat P, Delansorne R, Daviet L. Small-molecule inhibitor
of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells. Mol
Cancer Ther. 2009 Aug;8(8):2286-95. doi: 10.1158/1535-7163.MCT-09-0097. Epub 2009
Aug 11. PubMed PMID: 19671755.

3: Lee KW, Cho JG, Kim CM, Kang AY, Kim M, Ahn BY, Chung SS, Lim KH, Baek KH,
Sung JH, Park KS, Park SG. Herpesvirus-associated ubiquitin-specific protease
(HAUSP) modulates peroxisome proliferator-activated receptor γ (PPARγ) stability
through its deubiquitinating activity. J Biol Chem. 2013 Nov 15;288(46):32886-96.
doi: 10.1074/jbc.M113.496331. Epub 2013 Sep 26. PubMed PMID: 24072712; PubMed
Central PMCID: PMC3829140.