WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 407454
Description: MDK35833, also known as Oct3/4-inducer-1, is a potent Oct3/4-inducer. MDK35833 can promot expression and stabilization of Oct3/4 and enhance its transcriptional activity in diverse human somatic cells, implying the possible benefit from using this class of compounds in regenerative medicine.
MedKoo Cat#: 407454
Chemical Formula: C15H12FNO
Exact Mass: 241.0903
Molecular Weight: 241.2654
Elemental Analysis: C, 74.68; H, 5.01; F, 7.87; N, 5.81; O, 6.63
Synonym: Oct3/4-inducer-1, MDK35833; MDK-35833; MDK 35833.
IUPAC/Chemical Name: 4-[(4-Fluorophenyl)methoxy]-benzeneacetonitrile
InChi Key: PXFUNIXWNXRVEJ-UHFFFAOYSA-N
InChi Code: InChI=1S/C15H12FNO/c16-14-5-1-13(2-6-14)11-18-15-7-3-12(4-8-15)9-10-17/h1-8H,9,11H2
SMILES Code: N#CCC1=CC=C(OCC2=CC=C(F)C=C2)C=C1
CBP (CREB (cAMP responsive element binding protein) binding protein (CREBBP)) and P300 (adenovirus E1A-associated 300 kDa protein) are two closely related histone acetyltransferases (HATs) that play a key role in the regulation of gene transcription. Both proteins contain a bromodomain flanking the HAT catalytic domain that is important for the targeting of CBP/P300 to chromatin and which offeres an opportunity for the development of protein-protein interaction inhibitors.
1: Popp TA, Tallant C, Rogers C, Fedorov O, Brennan PE, Müller S, Knapp S,
Bracher F. Development of Selective CBP/P300 Benzoxazepine Bromodomain
Inhibitors. J Med Chem. 2016 Oct 13;59(19):8889-8912. Epub 2016 Sep 27. PubMed