MDK83190
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407448

CAS#: 79183-19-0

Description: MDK83190, also known as Apoptosis Activator 2, is an Apoptosis Activator. MDK83190 has CAS#79183-19-0, in which the last 5 digit was used for its name for easier communication. MDK83190 has been shown to induce apoptosis in leukemia cells (IC50 = 4-9 μM) .

Chemical Structure

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MDK83190
CAS# 79183-19-0
Instruction

Theoretical Analysis

MedKoo Cat#: 407448
Name: MDK83190
CAS#: 79183-19-0
Chemical Formula: C15H9Cl2NO2
Exact Mass: 305.00
Molecular Weight: 306.142
Elemental Analysis: C, 58.85; H, 2.96; Cl, 23.16; N, 4.58; O, 10.45

Price and Availability

Size Price Availability Quantity
50mg USD 250 2 Weeks
1g USD 2950 2 weeks
2g USD 4250 2 weeks
Bulk inquiry

Synonym: Apoptosis Activator 2; AAII; N-(3,4-dichlorobenzyl) Isatin. MDK83190; MDK-83190; MDK 83190.

IUPAC/Chemical Name: 1-[(3,4-dichlorophenyl)methyl]-1H-indole-2,3-dione

InChi Key: KGRJPLRFGLMQMV-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H9Cl2NO2/c16-11-6-5-9(7-12(11)17)8-18-13-4-2-1-3-10(13)14(19)15(18)20/h1-7H,8H2

SMILES Code: O=C1N(CC2=CC=C(Cl)C(Cl)=C2)C3=C(C=CC=C3)C1=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 306.14 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Nguyen JT, Wells JA. Direct activation of the apoptosis machinery as a
mechanism to target cancer cells. Proc Natl Acad Sci U S A. 2003 Jun
24;100(13):7533-8. Epub 2003 Jun 13. PubMed PMID: 12808146; PubMed Central PMCID:
PMC164621.