NIBR3049 | TCS-21311 | CAS#1260181-14-3 | JAK3 inhibitor

NIBR3049
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 206831

CAS#: 1260181-14-3

Description: NIBR3049, also known as TCS-21311, is a potent and selective JAK3 inhibitor IC50 values of 8 nM..

Chemical Structure

NIBR3049

CAS# 1260181-14-3

Product data Instruction

Theoretical Analysis

MedKoo Cat#: 206831
Name: NIBR3049
CAS#: 1260181-14-3
Chemical Formula: C27H25F3N4O4
Exact Mass: 526.18
Molecular Weight: 526.516
Elemental Analysis: C, 61.59; H, 4.79; F, 10.82; N, 10.64; O, 12.15

Price and Availability

Size	Price	Availability
5mg	USD 350	2 Weeks
10mg	USD 650	2 Weeks
25mg	USD 1150	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: NIBR3049; NIBR-3049; NIBR 3049; TCS-21311; TCS 21311; TCS21311.

IUPAC/Chemical Name: 3-[5-[4-(2-Hydroxy-2-methyl-1-oxopropyl)-1-piperazinyl]-2-(trifluoromethyl)phenyl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione

InChi Key: CLGRAWDGLMENOD-UHFFFAOYSA-N

InChi Code: InChI=1S/C27H25F3N4O4/c1-26(2,38)25(37)34-11-9-33(10-12-34)15-7-8-19(27(28,29)30)17(13-15)21-22(24(36)32-23(21)35)18-14-31-20-6-4-3-5-16(18)20/h3-8,13-14,31,38H,9-12H2,1-2H3,(H,32,35,36)

SMILES Code: O=C(C(C1=CC(N2CCN(C(C(C)(O)C)=O)CC2)=CC=C1C(F)(F)F)=C3C4=CNC5=C4C=CC=C5)NC3=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:

Product Data

Instruction:

View handling instruction

Biological target:	TCS 21311 (NIBR3049) is a potent, highly selective JAK3 inhibitor with an IC50 of 8 nM.
In vitro activity:	Here, by performing chemical screening for BMP substitutes, this study identified a small molecule, TCS21311, that can replace BMP7 and revealed a novel inhibitory role of BMP7 in JAK3-STAT3 signaling in NPC expansion culture. Further, this study found that TCS21311 facilitates the proliferation of mouse embryonic NPCs and human induced pluripotent stem cell-derived NPCs when added to the expansion culture. Reference: Biochem Biophys Res Commun. 2021 Jun 18;558:231-238. https://pubmed.ncbi.nlm.nih.gov/32113685/
In vivo activity:	TBD

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	67.6	128.30

Preparing Stock Solutions

The following data is based on the product molecular weight 526.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:	Tsujimoto H, Araoka T, Nishi Y, Ohta A, Nakahata T, Osafune K. Small molecule TCS21311 can replace BMP7 and facilitate cell proliferation in in vitro expansion culture of nephron progenitor cells. Biochem Biophys Res Commun. 2021 Jun 18;558:231-238. doi: 10.1016/j.bbrc.2020.02.130. Epub 2020 Feb 26. PMID: 32113685.
In vitro protocol:	Tsujimoto H, Araoka T, Nishi Y, Ohta A, Nakahata T, Osafune K. Small molecule TCS21311 can replace BMP7 and facilitate cell proliferation in in vitro expansion culture of nephron progenitor cells. Biochem Biophys Res Commun. 2021 Jun 18;558:231-238. doi: 10.1016/j.bbrc.2020.02.130. Epub 2020 Feb 26. PMID: 32113685.
In vivo protocol:	TBD

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