S107 HCl
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530577

CAS#: 927871-76-9

Description: S107 is a Type 1 ryanodine receptor (RyR1) stabilizer; binds RyR1 and enhances the binding affinity of calstabin-1. Inhibits Ca leak from the sarcoplasmic reticulum (SR).


Price and Availability

Size
Price

100mg
USD 950
1g
USD 3150
Size
Price

200mg
USD 1450
2g
USD 4750
Size
Price

500mg
USD 2250
5g
USD 7850

S107, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 530577
Name: S107 HCl
CAS#: 927871-76-9
Chemical Formula: C11H16ClNOS
Exact Mass:
Molecular Weight: 245.765
Elemental Analysis: C, 53.76; H, 6.56; Cl, 14.42; N, 5.70; O, 6.51; S, 13.04


Synonym: S107; S-107; S 107.

IUPAC/Chemical Name: 2,3,4,5-Tetrahydro-7-methoxy-4-methyl-1,4-benzothiazepine hydrochloride

InChi Key: PKLKSAHANRLKJK-UHFFFAOYSA-N

InChi Code: InChI=1S/C11H15NOS.ClH/c1-12-5-6-14-11-4-3-10(13-2)7-9(11)8-12;/h3-4,7H,5-6,8H2,1-2H3;1H

SMILES Code: CN1CCSC2=CC=C(OC)C=C2C1.[H]Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Mei Y, Xu L, Kramer HF, Tomberlin GH, Townsend C, Meissner G. Stabilization of the skeletal muscle ryanodine receptor ion channel-FKBP12 complex by the 1,4-benzothiazepine derivative S107. PLoS One. 2013;8(1):e54208. doi: 10.1371/journal.pone.0054208. Epub 2013 Jan 17. PubMed PMID: 23349825; PubMed Central PMCID: PMC3547879.

2: Kreko-Pierce T, Azpurua J, Mahoney RE, Eaton BA. Extension of Health Span and Life Span in Drosophila by S107 Requires the calstabin Homologue FK506-BP2. J Biol Chem. 2016 Dec 9;291(50):26045-26055. Epub 2016 Nov 1. PubMed PMID: 27803160; PubMed Central PMCID: PMC5207075.

3: Sasaki K, Makiyama T, Yoshida Y, Wuriyanghai Y, Kamakura T, Nishiuchi S, Hayano M, Harita T, Yamamoto Y, Kohjitani H, Hirose S, Chen J, Kawamura M, Ohno S, Itoh H, Takeuchi A, Matsuoka S, Miura M, Sumitomo N, Horie M, Yamanaka S, Kimura T. Patient-Specific Human Induced Pluripotent Stem Cell Model Assessed with Electrical Pacing Validates S107 as a Potential Therapeutic Agent for Catecholaminergic Polymorphic Ventricular Tachycardia. PLoS One. 2016 Oct 20;11(10):e0164795. doi: 10.1371/journal.pone.0164795. eCollection 2016. PubMed PMID: 27764147; PubMed Central PMCID: PMC5072719.

4: Beuck S, Schänzer W, Thevis M. Investigation of the in vitro metabolism of the emerging drug candidate S107 for doping-preventive purposes. J Mass Spectrom. 2011 Feb;46(2):112-30. doi: 10.1002/jms.1878. Epub 2011 Jan 21. PubMed PMID: 21254313.

5: Ahmed MA, De Avila M, Polverini E, Bessonov K, Bamm VV, Harauz G. Solution nuclear magnetic resonance structure and molecular dynamics simulations of a murine 18.5 kDa myelin basic protein segment (S72-S107) in association with dodecylphosphocholine micelles. Biochemistry. 2012 Sep 25;51(38):7475-87. doi: 10.1021/bi300998x. Epub 2012 Sep 14. PubMed PMID: 22947219.

6: Pennell CA. Selection for S107-V11 gene expression by peritoneal B cells in adult mice. J Immunol. 1995 Aug 1;155(3):1264-75. PubMed PMID: 7636194.

7: Fowler JF Jr. Facial Dermatitis and Rosacea. Semin Cutan Med Surg. 2016 Jun;35(6 Suppl):S107-9. doi: 10.12788/j.sder.2016.034. PubMed PMID: 27537212.

8: White R, Tran TA, Dankenbring CA, Deaton J, Young R. The N-terminal transmembrane domain of lambda S is required for holin but not antiholin function. J Bacteriol. 2010 Feb;192(3):725-33. doi: 10.1128/JB.01263-09. Epub 2009 Nov 6. PubMed PMID: 19897658; PubMed Central PMCID: PMC2812449.

9: Baumann B, Kistler B, Kirillov A, Bergman Y, Wirth T. The mutant plasmacytoma cell line S107 allows the identification of distinct pathways leading to NF-kappaB activation. J Biol Chem. 1998 May 8;273(19):11448-55. PubMed PMID: 9565556.

10: Cary S, Krishnan M, Marion TN, Silverman GJ. The murine clan V(H) III related 7183, J606 and S107 and DNA4 families commonly encode for binding to a bacterial B cell superantigen. Mol Immunol. 1999 Aug;36(11-12):769-76. PubMed PMID: 10593515.

11: Shan J, Xie W, Betzenhauser M, Reiken S, Chen BX, Wronska A, Marks AR. Calcium leak through ryanodine receptors leads to atrial fibrillation in 3 mouse models of catecholaminergic polymorphic ventricular tachycardia. Circ Res. 2012 Aug 31;111(6):708-17. doi: 10.1161/CIRCRESAHA.112.273342. Epub 2012 Jul 24. PubMed PMID: 22828895; PubMed Central PMCID: PMC3734386.

12: Steiner M, Bläsi U. Charged amino-terminal amino acids affect the lethal capacity of Lambda lysis proteins S107 and S105. Mol Microbiol. 1993 May;8(3):525-33. PubMed PMID: 8326864.

13: Graschopf A, Bläsi U. Molecular function of the dual-start motif in the lambda S holin. Mol Microbiol. 1999 Aug;33(3):569-82. PubMed PMID: 10417647.

14: Jiang Y, Khan FA, Pandupuspitasari NS, Kadariya I, Cheng Z, Ren Y, Chen X, Zhou A, Yang L, Kong D, Zhang S. Analysis of the binding sites of porcine sialoadhesin receptor with PRRSV. Int J Mol Sci. 2013 Dec 9;14(12):23955-79. doi: 10.3390/ijms141223955. PubMed PMID: 24351868; PubMed Central PMCID: PMC3876088.

15: Deaton J, Savva CG, Sun J, Holzenburg A, Berry J, Young R. Solubilization and delivery by GroEL of megadalton complexes of the lambda holin. Protein Sci. 2004 Jul;13(7):1778-86. PubMed PMID: 15215521; PubMed Central PMCID: PMC2279943.

16: Kwan SP, Max EE, Seidman JG, Leder P, Scharff MD. Two kappa immunoglobulin genes are expressed in the myeloma S107. Cell. 1981 Oct;26(1 Pt 1):57-66. PubMed PMID: 6799208.

17: Stewart GA, Turner KJ. Physicochemical and immunochemical characterization of the high molecular weight allergens from dermatophagoides pteronysisinus with particular reference to the tridacnin, Con-A and S107 reactive components. Aust J Exp Biol Med Sci. 1980 Jun;58(3):275-88. PubMed PMID: 7458776.

18: Yeh LC, Falcon WE, Garces A, Lee JC, Lee JC. A host-guest relationship in bone morphogenetic protein receptor-II defines specificity in ligand-receptor recognition. Biochemistry. 2012 Sep 4;51(35):6968-80. doi: 10.1021/bi3003023. Epub 2012 Aug 23. PubMed PMID: 22894880; PubMed Central PMCID: PMC3481545.

19: Liu M, Lee DF, Chen CT, Yen CJ, Li LY, Lee HJ, Chang CJ, Chang WC, Hsu JM, Kuo HP, Xia W, Wei Y, Chiu PC, Chou CK, Du Y, Dhar D, Karin M, Chen CH, Hung MC. IKKα activation of NOTCH links tumorigenesis via FOXA2 suppression. Mol Cell. 2012 Jan 27;45(2):171-84. doi: 10.1016/j.molcel.2011.11.018. Epub 2011 Dec 22. PubMed PMID: 22196886; PubMed Central PMCID: PMC3268914.

20: Giusti AM, Chien NC, Zack DJ, Shin SU, Scharff MD. Somatic diversification of S107 from an antiphosphocholine to an anti-DNA autoantibody is due to a single base change in its heavy chain variable region. Proc Natl Acad Sci U S A. 1987 May;84(9):2926-30. PubMed PMID: 3106981; PubMed Central PMCID: PMC304773.