Avapritinib
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MedKoo CAT#: 206816

CAS#: 1703793-34-3

Description: Avapritinib, also known as BlU-285, is a potent and selective inhibitor of PDGFRα D842V and KIT Exon 17 mutants and is being developed as a highly targeted therapy for SM, a disorder of the mast cells in which a KIT Exon 17 mutation is the primary driver of disease. BLU-285 is currently being developed by Blueprint.


Price and Availability

Size
Price

10mg
USD 350
100mg
USD 1450
1g
USD 4950
Size
Price

25mg
USD 650
200mg
USD 1950
2g
USD 6850
Size
Price

50mg
USD 950
500mg
USD 3459
5g
Ask price

Avapritinib (BLU-285), purity > 98%, is in stock. The same day shipping out after order is received. Note: the estimated shipping out time for order > 500mg may be 2 weeks..


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 206816
Name: Avapritinib
CAS#: 1703793-34-3
Chemical Formula: C26H27FN10
Exact Mass: 498.2404
Molecular Weight: 498.5704
Elemental Analysis: C, 62.64; H, 5.46; F, 3.81; N, 28.09


Synonym: BLU-285; BLU 285; BLU285, Avapritinib

IUPAC/Chemical Name: (S)-1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazin-1-yl)pyrimidin-5-yl)ethan-1-amine

InChi Key: DWYRIWUZIJHQKQ-SANMLTNESA-N

InChi Code: InChI=1S/C26H27FN10/c1-26(28,20-3-5-22(27)6-4-20)21-13-29-25(30-14-21)36-9-7-35(8-10-36)24-23-11-18(16-37(23)33-17-31-24)19-12-32-34(2)15-19/h3-6,11-17H,7-10,28H2,1-2H3/t26-/m0/s1

SMILES Code: CN1N=CC(C2=CN3C(C(N4CCN(C5=NC=C([C@@](C)(N)C6=CC=C(F)C=C6)C=N5)CC4)=NC=N3)=C2)=C1


Technical Data

Appearance:
White to off-white solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (MSDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: BLU-285, DCC-2618 Show Activity against GIST. Cancer Discov. 2017 Feb;7(2):121-122. doi: 10.1158/2159-8290.CD-NB2016-165. Epub 2017 Jan 11. PubMed PMID: 28077435.