Naltiazem

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 528523

CAS#: 108383-95-5

Description: Naltiazem, also known as RO-236152, is a calcium channel antagonist potentially for the treatment of arrhythmias, hypertension and myocardial infarction.


Price and Availability

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Naltiazem (RO-236152) is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 528523
Name: Naltiazem
CAS#: 108383-95-5
Chemical Formula: C26H28N2O4S
Exact Mass: 464.177
Molecular Weight: 464.58
Elemental Analysis: C, 67.22; H, 6.08; N, 6.03; O, 13.78; S, 6.90


Synonym: Naltiazem; RO-236152; RO 236152; RO236152

IUPAC/Chemical Name: (2S,3S)-5-(2-(dimethylamino)ethyl)-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydronaphtho[1,2-b][1,4]thiazepin-3-yl acetate

InChi Key: GWVJLVHNKMLXRM-RPWUZVMVSA-N

InChi Code: InChI=1S/C26H28N2O4S/c1-17(29)32-23-24(19-9-12-20(31-4)13-10-19)33-25-21-8-6-5-7-18(21)11-14-22(25)28(26(23)30)16-15-27(2)3/h5-14,23-24H,15-16H2,1-4H3/t23-,24+/m1/s1

SMILES Code: O=C1N(CCN(C)C)C2=CC=C3C=CC=CC3=C2S[C@@H](C4=CC=C(OC)C=C4)[C@H]1OC(C)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Davis PP, Choma N, Crews T, Fukuda EK. Quantitative determination of naltiazem in human plasma by gas chromatography/mass spectrometry. Biomed Environ Mass Spectrom. 1989 Nov;18(11):978-82. PubMed PMID: 2620159.