Nicousamide

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 528826

CAS#: 704881-43-6

Description: Nicousamide is a TGF-β inhibitor potentially for the treatment of renal insufficiency.


Chemical Structure

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Nicousamide
CAS# 704881-43-6

Theoretical Analysis

MedKoo Cat#: 528826
Name: Nicousamide
CAS#: 704881-43-6
Chemical Formula: C18H12N2O9
Exact Mass: 400.05
Molecular Weight: 400.290
Elemental Analysis: C, 54.01; H, 3.02; N, 7.00; O, 35.97

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym:

IUPAC/Chemical Name: 2-hydroxy-5-(7-hydroxy-8-methyl-6-nitro-2-oxo-2H-chromene-3-carboxamido)benzoic acid

InChi Key: DOLJMUVMVVSXRX-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H12N2O9/c1-7-14(22)12(20(27)28)5-8-4-11(18(26)29-15(7)8)16(23)19-9-2-3-13(21)10(6-9)17(24)25/h2-6,21-22H,1H3,(H,19,23)(H,24,25)

SMILES Code: O=C(O)C1=CC(NC(C2=CC3=CC([N+]([O-])=O)=C(O)C(C)=C3OC2=O)=O)=CC=C1O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 400.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Qi W, Zhao Q, Liu H, Jiang J, Chen X, Hu P. Determination of nicousamide in human plasma by liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal. 2013 Apr 15;77:158-62. doi: 10.1016/j.jpba.2013.01.025. Epub 2013 Jan 26. PubMed PMID: 23416370.

2: Zhang S, Li H, Li Y, Zhang F, Liu Y, Chen X. Nicousamide normalizes renovascular hypertension in two-kidney one-clip hypertensive rats. Biomed Rep. 2013 Jan;1(1):89-92. Epub 2012 Oct 22. PubMed PMID: 24648900; PubMed Central PMCID: PMC3956876.

3: Li H, Zhang Y, Wang H, Zheng X, Chen X. Nicousamide blocks the effects of advanced glycation end products on renal cells. Eur J Pharmacol. 2012 Jan 15;674(2-3):455-9. doi: 10.1016/j.ejphar.2011.06.056. Epub 2011 Jul 13. PubMed PMID: 21763303.

4: Sheng L, Hu JP, Chen H, Li Y. [Metabolism of nicousamide in rat and human liver in vitro]. Yao Xue Xue Bao. 2008 Sep;43(9):912-6. Chinese. PubMed PMID: 19048781.

5: Zhang S, Wang D, Xue N, Lai F, Ji M, Jin J, Chen X. Nicousamide protects kidney podocyte by inhibiting the TGFβ receptor II phosphorylation and AGE-RAGE signaling. Am J Transl Res. 2017 Jan 15;9(1):115-125. eCollection 2017 Jan 15. PubMed PMID: 28123638; PubMed Central PMCID: PMC5250708.

6: Sheng L, Chen H, Li Y. A HPLC method for determination of nicousamide in dog plasma and its application to pharmacokinetic studies. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Jul 1;854(1-2):99-103. Epub 2007 Apr 13. PubMed PMID: 17452131.

7: Zhang S, Li Y, Li H, Zheng X, Chen X. Renal-protective effect of nicousamide on hypertensive nephropathy in spontaneously hypertensive rats. Biomed Rep. 2013 Jan;1(1):34-40. Epub 2012 Sep 25. PubMed PMID: 24648890; PubMed Central PMCID: PMC3956899.