Dexamethasone cipecilate

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MedKoo CAT#: 329617

CAS#: 132245-57-9 (cipecilate)

Description: Dexamethasone cipecilate, also known as NS-126, is a novel, highly lipophilic anti-inflammatory corticosteroid. NS-126 is a long-acting intranasal corticosteroid and a promising therapeutic agent for allergic rhinitis.

Chemical Structure

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Dexamethasone cipecilate
CAS# 132245-57-9 (cipecilate)
Instruction

Theoretical Analysis

MedKoo Cat#: 329617
Name: Dexamethasone cipecilate
CAS#: 132245-57-9 (cipecilate)
Chemical Formula: C33H43FO7
Exact Mass: 570.30
Molecular Weight: 570.698
Elemental Analysis: C, 69.45; H, 7.59; F, 3.33; O, 19.62

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
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Related CAS #: 3936-02-5 (metasulfobenzoate sodium)   3800-84-8 (sodium succinate)   50-02-2 (free base)   1177-87-3 (acetate)   150587-07-8 (beloxil)   2265-64-7 (isonicotinate)   14899-36-6 (palmitate)   312-93-6 (phosphate)   2392-39-4 (phosphate sodium)  

Synonym: Dexamethasone cipecilate; NS-126; NS 126; NS126.

IUPAC/Chemical Name: 2-((8S,9R,10S,11S,13S,14S,16R,17R)-17-((cyclopropanecarbonyl)oxy)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl cyclohexanecarboxylate

InChi Key: JPTKVJWWVFLEJL-GVPGRCOTSA-N

InChi Code: InChI=1S/C33H43FO7/c1-19-15-25-24-12-11-22-16-23(35)13-14-30(22,2)32(24,34)26(36)17-31(25,3)33(19,41-29(39)21-9-10-21)27(37)18-40-28(38)20-7-5-4-6-8-20/h13-14,16,19-21,24-26,36H,4-12,15,17-18H2,1-3H3/t19-,24+,25+,26+,30+,31+,32+,33+/m1/s1

SMILES Code: O=C(C1CCCCC1)OCC([C@@]2(OC(C3CC3)=O)[C@H](C)C[C@@]4([H])[C@]5([H])CCC6=CC(C=C[C@]6(C)[C@@]5(F)[C@@H](O)C[C@]24C)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 570.70 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Sasagawa T, Yamada T, Nakagawa T, Tsujioka T, Takahashi Y, Kawakita N, Nonaka K, Nakamura A. In vitro metabolism of dexamethasone cipecilate, a novel synthetic corticosteroid, in human liver and nasal mucosa. Xenobiotica. 2011 Oct;41(10):874-84. doi: 10.3109/00498254.2011.582894. Epub 2011 Jun 10. PubMed PMID: 21657966.

2: Yu SQ, Wang DH. Enhanced salt sensitivity following shRNA silencing of neuronal TRPV1 in rat spinal cord. Acta Pharmacol Sin. 2011 Jun;32(6):845-52. doi: 10.1038/aps.2011.43. PubMed PMID: 21642952; PubMed Central PMCID: PMC4009958.

3: Gotoh M, Okubo K, Okuda M, Hamada C. Clinical pharmacology study of the corticosteroid nasal spray dexamethasone cipecilate (NS-126): examination of the durability of efficacy in the nasal induction test. Expert Opin Investig Drugs. 2010 Dec;19(12):1475-86. doi: 10.1517/13543784.2010.531258. Epub 2010 Nov 11. PubMed PMID: 21067470.

4: Inoue N, Hashino A, Kageyama K, Zhang X, Sasagawa T, Kawakita N, Takahashi Y, Yoshida K, Hashimoto M, Mori K, Kyoi T. Pharmacological profile of the novel anti-inflammatory corticosteroid NS-126, a therapeutic agent for allergic rhinitis. J Pharmacol Sci. 2010;112(1):73-82. Epub 2010 Jan 6. PubMed PMID: 20051657.

5: Pech V, Sikka SC, Sindhu RK, Vaziri ND, Majid DS. Oxidant stress and blood pressure responses to angiotensin II administration in rats fed varying salt diets. Am J Hypertens. 2006 May;19(5):534-40. PubMed PMID: 16647629.

6: Etaugh C, Kelliher R, Osborne B, Rose M. The role of visual and haptic cues in children's discrimination learning. J Genet Psychol. 1981 Mar;138(1st Half):75-9. PubMed PMID: 7217924.