UR-7247

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 528422

CAS#: 177847-28-8

Description: UR-7247 is an angiotensin type 1 receptor antagonist potentially for the treatment of hypertension. UR-7247 has a very long plasma elimination half-life, which may be due to a high but also tight binding to protein binding sites.


Chemical Structure

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UR-7247
CAS# 177847-28-8

Theoretical Analysis

MedKoo Cat#: 528422
Name: UR-7247
CAS#: 177847-28-8
Chemical Formula: C24H26N6O2
Exact Mass: 430.21
Molecular Weight: 430.512
Elemental Analysis: C, 66.96; H, 6.09; N, 19.52; O, 7.43

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: UR-7247, UR 7247, UR7247

IUPAC/Chemical Name: 5-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-3-isopropyl-1-propyl-1H-pyrazole-4-carboxylic acid

InChi Key: FOVKKLYIXHRZPA-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H26N6O2/c1-4-13-30-20(21(24(31)32)22(27-30)15(2)3)14-16-9-11-17(12-10-16)18-7-5-6-8-19(18)23-25-28-29-26-23/h5-12,15H,4,13-14H2,1-3H3,(H,31,32)(H,25,26,28,29)

SMILES Code: O=C(C1=C(CC2=CC=C(C3=CC=CC=C3C4=NN=NN4)C=C2)N(CCC)N=C1C(C)C)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 430.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Maillard MP, Rossat J, Nussberger J, Ramis J, Pontes C, Burnier M, Brunner HR. Pharmacologic profile of UR-7247, an orally active angiotensin II AT1 receptor antagonist, in healthy volunteers. p6. J Cardiovasc Pharmacol. 2000 Mar;35(3):383-9. PubMed PMID: 10710122.