ZD-6888 Hydrochloride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 528421

CAS#: 138620-17-4

Description: ZD-6888 Hydrochloride, also known as ZD-6888 and ICI-D-6888, is an angiotensin type 1 receptor antagonist potentially for the treatment of hypertension.


Price and Availability

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ZD-6888 Hydrochloride (ICI-D-6888) is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 528421
Name: ZD-6888 Hydrochloride
CAS#: 138620-17-4
Chemical Formula: C25H26ClN5O
Exact Mass:
Molecular Weight: 447.967
Elemental Analysis: C, 67.03; H, 5.85; Cl, 7.91; N, 15.63; O, 3.57


Related CAS #: 138620-17-4 (HCl); 138620-04-9 (free)  

Synonym: ZD-6888; ZD 6888; ZD6888; ZD-6888 HCl; ICI-D-6888; ICI D 6888; ICID6888

IUPAC/Chemical Name: 4-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methoxy)-2-ethyl-5,6,7,8-tetrahydroquinoline hydrochloride

InChi Key: RPRNBLHRKYAXSM-UHFFFAOYSA-N

InChi Code: InChI=1S/C25H25N5O.ClH/c1-2-19-15-24(22-9-5-6-10-23(22)26-19)31-16-17-11-13-18(14-12-17)20-7-3-4-8-21(20)25-27-29-30-28-25;/h3-4,7-8,11-15H,2,5-6,9-10,16H2,1H3,(H,27,28,29,30);1H

SMILES Code: CCC1=NC2=C(CCCC2)C(OCC3=CC=C(C4=CC=CC=C4C5=NNN=N5)C=C3)=C1.[H]Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Jackson DG, Jones HB. Histopathological and ultrastructural changes in the juxtaglomerular apparatus of the rat following administration of ZENECA ZD6888 (2-ethyl-5,6,7,8-tetrahydro-4-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)- methoxy]quinoline), an angiotensin II antagonist. Toxicol Pathol. 1995 Jan-Feb;23(1):7-15. PubMed PMID: 7770702.

2: Bradbury RH, Allott CP, Dennis M, Girdwood JA, Kenny PW, Major JS, Oldham AA, Ratcliffe AH, Rivett JE, Roberts DA, et al. New nonpeptide angiotensin II receptor antagonists. 3. Synthesis, biological properties, and structure-activity relationships of 2-alkyl-4-(biphenylylmethoxy)pyridine derivatives. J Med Chem. 1993 Apr 30;36(9):1245-54. PubMed PMID: 8487261.