XMU-MP-1
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530548

CAS#: 2061980-01-4

Description: XMU-MP-1 is a potent and selective MST1/2 inhibitor with IC50 values of 71.1 ± 12.9 nM and 38.1 ± 6.9 nM, respectively.. XMU-MP-1 blocked MST1/2 kinase activities, thereby activating the downstream effector Yes-associated protein and promoting cell growth. XMU-MP-1 displayed excellent in vivo pharmacokinetics and was able to augment mouse intestinal repair, as well as liver repair and regeneration, in both acute and chronic liver injury mouse models at a dose of 1 to 3 mg/kg via intraperitoneal injection.


Price and Availability

Size
Price

10mg
USD 190
100mg
USD 950
1g
USD 3450
Size
Price

25mg
USD 350
200mg
USD 1450
5g
USD 8650
Size
Price

50mg
USD 650
500mg
USD 2150

XMU-MP-1, purity > 98%, is in stock. The same day shipping out after order is received. Note: the estimated shipping out time for order > 1.5g may be 2 weeks.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 530548
Name: XMU-MP-1
CAS#: 2061980-01-4
Chemical Formula: C17H16N6O3S2
Exact Mass: 416.0725
Molecular Weight: 416.474
Elemental Analysis: C, 49.03; H, 3.87; N, 20.18; O, 11.52; S, 15.40


Synonym: XMU-MP-1; XMU-MP1; XMU-MP 1; XMUMP-1; XMUMP1; XMUMP 1.

IUPAC/Chemical Name: 4-((5,10-dimethyl-6-oxo-6,10-dihydro-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino)benzenesulfonamide

InChi Key: YRDHKIFCGOZTGD-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H16N6O3S2/c1-22-12-7-8-27-14(12)16(24)23(2)13-9-19-17(21-15(13)22)20-10-3-5-11(6-4-10)28(18,25)26/h3-9H,1-2H3,(H2,18,25,26)(H,19,20,21)

SMILES Code: O=S(C1=CC=C(NC2=NC=C3C(N(C)C(C=CS4)=C4C(N3C)=O)=N2)C=C1)(N)=O


Technical Data

Appearance:
Light yellow to yellow solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (MSDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Fan F, He Z, Kong LL, Chen Q, Yuan Q, Zhang S, Ye J, Liu H, Sun X, Geng J, Yuan L, Hong L, Xiao C, Zhang W, Sun X, Li Y, Wang P, Huang L, Wu X, Ji Z, Wu Q, Xia NS, Gray NS, Chen L, Yun CH, Deng X, Zhou D. Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration. Sci Transl Med. 2016 Aug 17;8(352):352ra108. doi: 10.1126/scitranslmed.aaf2304. PubMed PMID: 27535619.