CCG-232601

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530527

CAS#: 1922099-21-5

Description: CCG-232601 is a inhibitor of the Rho/MRTF/SRF transcriptional pathway as potential antifibrotic therapeutics for systemic scleroderma. CCG-232601 has SRE. L IC50= 550 nM; MLM T1/2 = 7.8 min; Aq sol = 23ug/mL; Plasma AUC 0-7h (10mg/kg) = 15250 hr.ng/mL. CCG-232601 could inhibit the development of bleomycin-induced dermal fibrosis in mice when administered orally at 50 mg/kg.

Chemical Structure

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CCG-232601
CAS# 1922099-21-5
Instruction

Theoretical Analysis

MedKoo Cat#: 530527
Name: CCG-232601
CAS#: 1922099-21-5
Chemical Formula: C24H20ClF2N3O2
Exact Mass: 455.12
Molecular Weight: 455.890
Elemental Analysis: C, 63.23; H, 4.42; Cl, 7.78; F, 8.33; N, 9.22; O, 7.02

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: CCG-232601; CCG 232601; CCG232601.

IUPAC/Chemical Name: N-(4-chlorophenyl)-5,5-difluoro-1-(3-(pyridin-4-yl)benzoyl)piperidine-3-carboxamide

InChi Key: MKJLDLGLVZUENS-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H20ClF2N3O2/c25-20-4-6-21(7-5-20)29-22(31)19-13-24(26,27)15-30(14-19)23(32)18-3-1-2-17(12-18)16-8-10-28-11-9-16/h1-12,19H,13-15H2,(H,29,31)

SMILES Code: O=C(N1CC(F)(F)CC(C(NC2=CC=C(Cl)C=C2)=O)C1)C3=CC(C4=CC=NC=C4)=CC=C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 455.89 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Pharmacokinetic optimitzation of CCG-203971: Novel inhibitors of the Rho/MRTF/SRF transcriptional pathway as potential antifibrotic therapeutics for systemic scleroderma
In Press, Corrected Proof, Available online 10 March 2017
Kim M. Hutchings, Erika M. Lisabeth, Walajapet Rajeswaran, Michael W. Wilson, Roderick J. Sorenson, Phillip L. Campbell, Jeffrey H. Ruth, Asif Amin, Pei-Suen Tsou, Jeffrey R. Leipprandt, Samuel R. Olson, Bo Wen, Ting Zhao, Duxin Sun, Dinesh Khanna, David A. Fox, Richard R. Neubig, Scott D. Larsen