ZK-95962

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 528410

CAS#: 101071-43-6

Description: ZK-95962 is a gamma-aminobutyric acid (GABA) receptor agonist potentially for the treatment of anxiety disorders. ZK-95962 had selective effects on releasing exploratory locomotor activity suppressed by footshock (punished crossings). ZK-95962 had weak effects on the measures of anxiolytic activity. The feelings of uneasiness and myoclonic jerks, provoked by photostimulation, were also abolished by ZK-95962.


Price and Availability

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ZK-95962 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 528410
Name: ZK-95962
CAS#: 101071-43-6
Chemical Formula: C19H22N2O4
Exact Mass: 342.158
Molecular Weight: 342.395
Elemental Analysis: C, 66.65; H, 6.48; N, 8.18; O, 18.69


Synonym: ZK-95962; ZK 95962; ZK95962

IUPAC/Chemical Name: ethyl 5-isopropoxy-4-(methoxymethyl)-9H-pyrido[3,4-b]indole-3-carboxylate

InChi Key: TXYZHYRYRRNVHR-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H22N2O4/c1-5-24-19(22)18-12(10-23-4)16-14(9-20-18)21-13-7-6-8-15(17(13)16)25-11(2)3/h6-9,11,21H,5,10H2,1-4H3

SMILES Code: O=C(C1=C(COC)C2=C(C=N1)NC3=C2C(OC(C)C)=CC=C3)OCC


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Kleven MS, Koek W. Effects of different classes of partial benzodiazepine agonists on punished and unpunished responding in pigeons. Psychopharmacology (Berl). 1999 Jun;144(4):405-10. PubMed PMID: 10435414.

2: Cole BJ, Hillmann M. Effects of benzodiazepine receptor ligands on the performance of an operant delayed matching to position task in rats: opposite effects of FG 7142 and lorazepam. Psychopharmacology (Berl). 1994 Jul;115(3):350-7. PubMed PMID: 7871075.

3: Jones GH, Schneider C, Schneider HH, Seidler J, Cole BJ, Stephens DN. Comparison of several benzodiazepine receptor ligands in two models of anxiolytic activity in the mouse: an analysis based on fractional receptor occupancies. Psychopharmacology (Berl). 1994 Mar;114(2):191-9. PubMed PMID: 7838907.

4: Krause W, Dorow R. Pharmacokinetics of two partial benzodiazepine receptor agonistic beta-carboline derivatives in healthy volunteers. Arzneimittelforschung. 1993 May;43(5):511-5. PubMed PMID: 8392343.

5: Andrews JS, Stephens DN. Discriminative stimulus properties of the benzodiazepine receptor partial agonist beta-carbolines abecarnil and ZK 95962: a comparison with chlordiazepoxide. Behav Pharmacol. 1991 Jun;2(3):171-185. PubMed PMID: 11224061.

6: Turner DM, Sapp DW, Olsen RW. The benzodiazepine/alcohol antagonist Ro 15-4513: binding to a GABAA receptor subtype that is insensitive to diazepam. J Pharmacol Exp Ther. 1991 Jun;257(3):1236-42. PubMed PMID: 1646328.

7: Møller A, Jensen LH, Skrumsager B, Blatt-Lyon B, Pedersen B, Dam M. Inhibition of photosensitive seizures in man by the beta-carboline, ZK 95962, a selective benzodiazepine receptor agonist. Epilepsy Res. 1990 Mar;5(2):155-9. PubMed PMID: 2158440.

8: Chapman AG, De Sarro GB, Premachandra M, Meldrum BS. Bidirectional effects of beta-carbolines in reflex epilepsy. Brain Res Bull. 1987 Sep;19(3):337-46. PubMed PMID: 3119161.