L-739750

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 532075

CAS#: 160141-08-2

Description: L-739,750 is a peptidomimetic farnesyltransferase inhibitor (FTI).


Price and Availability

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L-739750 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 532075
Name: L-739750
CAS#: 160141-08-2
Chemical Formula: C23H39N3O6S2
Exact Mass: 517.228
Molecular Weight: 517.7
Elemental Analysis: C, 53.36; H, 7.59; N, 8.12; O, 18.54; S, 12.39


Synonym: L-739750; L 739750; L739750.

IUPAC/Chemical Name: (2S)-2-[[(2S)-2-[(2S,3S)-2-[[(2R)-2-amino-3-sulfanylpropyl]amino]-3-methylpentoxy]-3-phenylpropanoyl]amino]-4-methylsulfonylbutanoic acid

InChi Key: SIEXHGZWGJLLAC-OSTWSGHESA-N

InChi Code: InChI=1S/C23H39N3O6S2/c1-4-16(2)20(25-13-18(24)15-33)14-32-21(12-17-8-6-5-7-9-17)22(27)26-19(23(28)29)10-11-34(3,30)31/h5-9,16,18-21,25,33H,4,10-15,24H2,1-3H3,(H,26,27)(H,28,29)/t16-,18+,19-,20+,21-/m0/s1

SMILES Code: O=C(O)[C@@H](NC([C@@H](OC[C@@H](NC[C@@H](N)CS)[C@@H](C)CC)CC1=CC=CC=C1)=O)CCS(=O)(C)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Assem N, Yudin AK. Convergent synthesis of aminomethylene peptidomimetics. Nat Protoc. 2012 Jun 14;7(7):1327-34. doi: 10.1038/nprot.2012.066. PubMed PMID: 22722368.

2: Long SB, Hancock PJ, Kral AM, Hellinga HW, Beese LS. The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics. Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):12948-53. PubMed PMID: 11687658; PubMed Central PMCID: PMC60805.

3: Koblan KS, Culberson JC, Desolms SJ, Giuliani EA, Mosser SD, Omer CA, Pitzenberger SM, Bogusky MJ. NMR studies of novel inhibitors bound to farnesyl-protein transferase. Protein Sci. 1995 Apr;4(4):681-8. PubMed PMID: 7613466; PubMed Central PMCID: PMC2143100.

4: Kohl NE, Wilson FR, Mosser SD, Giuliani E, deSolms SJ, Conner MW, Anthony NJ, Holtz WJ, Gomez RP, Lee TJ, et al. Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice. Proc Natl Acad Sci U S A. 1994 Sep 13;91(19):9141-5. PubMed PMID: 8090782; PubMed Central PMCID: PMC44763.