L-736380

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 532074

CAS#: 152885-49-9

Description: L-736380, also known as L-736,380, is a CCK-B receptor antagonist. L-736,380 dose-dependently inhibited gastric acid secretion in anesthetized rats (ID(50), 0.064 mg/kg) and ex vivo binding of [(125)I]CCK-8S in BKTO mice brain membranes (ED(50), 1.7 mg/kg) and is one of the most potent acidic CCK-B receptor antagonists yet described.


Price and Availability

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L-736380 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 532074
Name: L-736380
CAS#: 152885-49-9
Chemical Formula: C25H29N9O2
Exact Mass: 487.2444
Molecular Weight: 487.57
Elemental Analysis: C, 61.59; H, 6.00; N, 25.86; O, 6.56


Synonym: L-736380; L 736380; L736380; L-736,380; L 736,380; L736,380.

IUPAC/Chemical Name: 1-[(3R)-5-cyclohexyl-1-methyl-2-oxo-3H-1,4-benzodiazepin-3-yl]-3-[3-(methyl-(2H-tetrazol-5-yl)amino)phenyl]urea

InChi Key: MYPNMQPMQUAOTH-QFIPXVFZSA-N

InChi Code: InChI=1S/C25H29N9O2/c1-33(24-29-31-32-30-24)18-12-8-11-17(15-18)26-25(36)28-22-23(35)34(2)20-14-7-6-13-19(20)21(27-22)16-9-4-3-5-10-16/h6-8,11-16,22H,3-5,9-10H2,1-2H3,(H2,26,28,36)(H,29,30,31,32)/t22-/m0/s1

SMILES Code: O=C(NC1=CC=CC(N(C)C2=NNN=N2)=C1)N[C@H]3C(N(C)C4=CC=CC=C4C(C5CCCCC5)=N3)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Castro JL, Ball RG, Broughton HB, Russell MG, Rathbone D, Watt AP, Baker R,
Chapman KL, Fletcher AE, Patel S, Smith AJ, Marshall GR, Ryecroft W, Matassa VG.
Controlled modification of acidity in cholecystokinin B receptor antagonists:
N-(1,4-benzodiazepin-3-yl)-N'-[3-(tetrazol-5-ylamino) phenyl]ureas. J Med Chem.
1996 Feb 16;39(4):842-9. PubMed PMID: 8632408.