L-703,606
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 532069

CAS#: 144425-84-3

Description: L-703,606 is a potent, selective antagonist to the human NK1 receptor.


Price and Availability

Size
Price

5mg
USD 220
Size
Price

Size
Price

L-703,606, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 532069
Name: L-703,606
CAS#: 144425-84-3
Chemical Formula: C27H29IN2
Exact Mass: 508.1375
Molecular Weight: 508.45
Elemental Analysis: C, 63.78; H, 5.75; I, 24.96; N, 5.51


Synonym: L-703,606; L 703,606; L703,606.

IUPAC/Chemical Name: (7R,8R)-7-[di(phenyl)methyl]-N-[(2-iodophenyl)methyl]-1-azabicyclo[2.2.2]octan-8-amine

InChi Key: WSLTYZVXORBNLB-KAYWLYCHSA-N

InChi Code: InChI=1S/C27H29IN2/c28-24-14-8-7-13-23(24)19-29-26-22-15-17-30(18-16-22)27(26)25(20-9-3-1-4-10-20)21-11-5-2-6-12-21/h1-14,22,25-27,29H,15-19H2/t26-,27-/m1/s1

SMILES Code: IC1=CC=CC=C1CN[C@H]2[C@@H](C(C3=CC=CC=C3)C4=CC=CC=C4)N5CCC2CC5


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Tao K, Wang HT, Chen B, Wang BT, Li ZY, Zhu XX, Tang CW, Hu DH. Effect of nonpeptide NK1 receptor antagonist L-703,606 on the edema formation in rats at early stage after deep partial-thickness skin scalding. Asian Pac J Trop Med. 2013 May 13;6(5):387-94. doi: 10.1016/S1995-7645(13)60044-9. PubMed PMID: 23608379.

2: Tao K, Chen B, Hu DH, Wang BT. [The influence of non-peptide NK1 receptor antagonist L-703, 606 on the early tissue edema formation in rats with deep partial-thickness scald]. Zhonghua Shao Shang Za Zhi. 2005 Dec;21(6):455-8. Chinese. PubMed PMID: 16480633.

3: Francis BE, Swain C, Sabin V, Burns HD. Radioiodinated L-703,606: a potent, selective antagonist to the human NK1 receptor. Appl Radiat Isot. 1994 Jan;45(1):97-103. PubMed PMID: 8287060.