L-694,247

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 532068

CAS#: 137403-12-4

Description: L-694,247 is a selective and extremely potent 5-HT1D receptor agonist.


Price and Availability

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L-694,247 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 532068
Name: L-694,247
CAS#: 137403-12-4
Chemical Formula: C20H21N5O3S
Exact Mass: 411.1365
Molecular Weight: 411.48
Elemental Analysis: C, 58.38; H, 5.14; N, 17.02; O, 11.66; S, 7.79


Synonym: L-694,247; L 694,247; L694,247.

IUPAC/Chemical Name: N-[4-[[5-[3-(2-aminoethyl)-1H-indol-5-yl]-1,2,4-oxadiazol-3-yl]methyl]phenyl]methanesulfonamide

InChi Key: HKXMQLISPYELRD-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H21N5O3S/c1-29(26,27)25-16-5-2-13(3-6-16)10-19-23-20(28-24-19)14-4-7-18-17(11-14)15(8-9-21)12-22-18/h2-7,11-12,22,25H,8-10,21H2,1H3

SMILES Code: CS(=O)(NC1=CC=C(CC2=NOC(C3=CC4=C(NC=C4CCN)C=C3)=N2)C=C1)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: De Castro-e-Silva E, Sarmento C, Nascimento TA, Luz CP, Soares T, Marinho A, Cunha M, Bulcäo C, De Oliveira IR, Fregoneze JB. Effect of third ventricle administration of L-694,247, a selective 5-HT1D receptor agonist, on water intake in rats. Pharmacol Biochem Behav. 1997 Aug;57(4):749-54. PubMed PMID: 9259002.

2: Heald A, Stanton JA, Osborne SA, Middlemiss DN, Beer MS. [3H]L-694,247 labels the 5-HT1D beta receptor in pig caudate membranes. Eur J Pharmacol. 1994 Oct 24;264(2):213-6. PubMed PMID: 7851485.

3: Beer MS, Stanton JA, Bevan Y, Heald A, Reeve AJ, Street LJ, Matassa VG, Hargreaves RJ, Middlemiss DN. L-694,247: a potent 5-HT1D receptor agonist. Br J Pharmacol. 1993 Nov;110(3):1196-200. PubMed PMID: 8298808; PubMed Central PMCID: PMC2175804.