L690330
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 532065

CAS#: 142523-38-4

Description: L690330 is a potent inhibitor of inositol monophophatase. L690330 induces autophagy in COS-7 cells independently of mTOR inhibition.


Price and Availability

Size
Price

10mg
USD 300
Size
Price

Size
Price

L690330, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 532065
Name: L690330
CAS#: 142523-38-4
Chemical Formula: C8H12O8P2
Exact Mass: 298.0007
Molecular Weight: 298.12
Elemental Analysis: C, 32.23; H, 4.06; O, 42.93; P, 20.78


Synonym: L690330; L 690330; L-690330.

IUPAC/Chemical Name: [1-(4-hydroxyphenoxy)-1-phosphonoethyl]phosphonic acid

InChi Key: JKOCAAWWDVHWKB-UHFFFAOYSA-N

InChi Code: InChI=1S/C8H12O8P2/c1-8(17(10,11)12,18(13,14)15)16-7-4-2-6(9)3-5-7/h2-5,9H,1H3,(H2,10,11,12)(H2,13,14,15)

SMILES Code: CC(OC1=CC=C(O)C=C1)(P(O)(O)=O)P(O)(O)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Shtein L, Toker L, Bersudsky Y, Belmaker RH, Agam G. The inositol monophosphatase inhibitor L-690,330 affects pilocarpine-behavior and the forced swim test. Psychopharmacology (Berl). 2013 Jun;227(3):503-8. doi: 10.1007/s00213-013-2969-0. PubMed PMID: 23344554.

2: Sarkar S, Rubinsztein DC. Inositol and IP3 levels regulate autophagy: biology and therapeutic speculations. Autophagy. 2006 Apr-Jun;2(2):132-4. Review. PubMed PMID: 16874097.

3: Westfall TA, Hjertos B, Slusarski DC. Requirement for intracellular calcium modulation in zebrafish dorsal-ventral patterning. Dev Biol. 2003 Jul 15;259(2):380-91. PubMed PMID: 12871708.

4: Sconzo G, Cascino D, Amore G, Geraci F, Giudice G. Effect of the IMPase inhibitor L690,330 on sea urchin development. Cell Biol Int. 1998;22(2):91-4. PubMed PMID: 9878095.

5: Cui H, Meng Y, Bulleit RF. Inhibition of glycogen synthase kinase 3beta activity regulates proliferation of cultured cerebellar granule cells. Brain Res Dev Brain Res. 1998 Dec 7;111(2):177-88. PubMed PMID: 9838099.

6: Piettre SR, André C, Chanal MC, Ducep JB, Lesur B, Piriou F, Raboisson P, Rondeau JM, Schelcher C, Zimmermann P, Ganzhorn AJ. Monoaryl- and bisaryldihydroxytropolones as potent inhibitors of inositol monophosphatase. J Med Chem. 1997 Dec 19;40(26):4208-21. PubMed PMID: 9435892.

7: Slusarski DC, Corces VG, Moon RT. Interaction of Wnt and a Frizzled homologue triggers G-protein-linked phosphatidylinositol signalling. Nature. 1997 Nov 27;390(6658):410-3. PubMed PMID: 9389482.

8: Atack JR. Inositol monophosphatase inhibitors--lithium mimetics? Med Res Rev. 1997 Mar;17(2):215-24. Review. PubMed PMID: 9057165.

9: Atack JR, Prior AM, Fletcher SR, Quirk K, McKernan R, Ragan CI. Effects of L-690,488, a prodrug of the bisphosphonate inositol monophosphatase inhibitor L-690,330, on phosphatidylinositol cycle markers. J Pharmacol Exp Ther. 1994 Jul;270(1):70-6. PubMed PMID: 8035344.

10: Atack JR, Cook SM, Watt AP, Fletcher SR, Ragan CI. In vitro and in vivo inhibition of inositol monophosphatase by the bisphosphonate L-690,330. J Neurochem. 1993 Feb;60(2):652-8. PubMed PMID: 8380439.