Adelmidrol
new
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 329603

CAS#: 1675-66-7

Description: Adelmidrol is the semisynthetic diethanolamide derivative of azelaic acid, and has a symmetrical chemical structure. It classed as an ALIAmide, and is similar to palmitoylethanolamide, the parent molecule in the ALIAmide class of drugs. It is used extensively in Italy in veterinary medicine, to treat skin inflammation. In 2015 it was found the compound also exerts anti-inflammatory action given systemically in 10 mg per kg bodyweigh


Price and Availability

Size
Price

200mg
USD 550
2g
USD 2450
Size
Price

500mg
USD 850
5g
USD 3950
Size
Price

1g
USD 1450

Adelmidrol, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 329603
Name: Adelmidrol
CAS#: 1675-66-7
Chemical Formula: C13H26N2O4
Exact Mass: 274.1893
Molecular Weight: 274.361
Elemental Analysis: C, 56.91; H, 9.55; N, 10.21; O, 23.33


Synonym: Adelmidrol

IUPAC/Chemical Name: N,N'-bis(2-Hydroxyethyl)nonanediamide

InChi Key: PAHZPHDAJQIETD-UHFFFAOYSA-N

InChi Code: InChI=1S/C13H26N2O4/c16-10-8-14-12(18)6-4-2-1-3-5-7-13(19)15-9-11-17/h16-17H,1-11H2,(H,14,18)(H,15,19)

SMILES Code: O=C(NCCO)CCCCCCCC(NCCO)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

ALIAmides are group of fatty acid derivatives with cannabimimetic properties, which have antiinflammatory and analgesic effects and are thought to act by reducing mast cell activation


References

1: Petrosino S, Puigdemont A, Della Valle MF, Fusco M, Verde R, Allarà M, Aveta T, Orlando P, Di Marzo V. Adelmidrol increases the endogenous concentrations of palmitoylethanolamide in canine keratinocytes and down-regulates an inflammatory reaction in an in vitro model of contact allergic dermatitis. Vet J. 2016 Jan;207:85-91. doi: 10.1016/j.tvjl.2015.10.060. PubMed PMID: 26639824.

2: Di Paola R, Fusco R, Impellizzeri D, Cordaro M, Britti D, Morittu VM, Evangelista M, Cuzzocrea S. Adelmidrol, in combination with hyaluronic acid, displays increased anti-inflammatory and analgesic effects against monosodium iodoacetate-induced osteoarthritis in rats. Arthritis Res Ther. 2016 Dec 12;18(1):291. PubMed PMID: 27955699; PubMed Central PMCID: PMC5153857.

3: Impellizzeri D, Di Paola R, Cordaro M, Gugliandolo E, Casili G, Morittu VM, Britti D, Esposito E, Cuzzocrea S. Adelmidrol, a palmitoylethanolamide analogue, as a new pharmacological treatment for the management of acute and chronic inflammation. Biochem Pharmacol. 2016 Nov 1;119:27-41. doi: 10.1016/j.bcp.2016.09.001. PubMed PMID: 27599446.

4: Cordaro M, Impellizzeri D, Gugliandolo E, Siracusa R, Crupi R, Esposito E, Cuzzocrea S. Adelmidrol, a Palmitoylethanolamide Analogue, as a New Pharmacological Treatment for the Management of Inflammatory Bowel Disease. Mol Pharmacol. 2016 Nov;90(5):549-561. PubMed PMID: 27625036.

5: Cerrato S, Brazis P, Della Valle MF, Miolo A, Puigdemont A. Inhibitory effect of topical adelmidrol on antigen-induced skin wheal and mast cell behavior in a canine model of allergic dermatitis. BMC Vet Res. 2012 Nov 26;8:230. doi: 10.1186/1746-6148-8-230. PubMed PMID: 23181761; PubMed Central PMCID: PMC3540011.

6: Indraccolo U, Scutiero G, Matteo M, Greco P. Effectiveness of vaginal adelmidrol for treating pelvic visceral discomforts and anxiety: a prospective observational study. Minerva Ginecol. 2013 Aug;65(4):465-70. PubMed PMID: 24051946.

7: De Filippis D, D'Amico A, Cinelli MP, Esposito G, Di Marzo V, Iuvone T. Adelmidrol, a palmitoylethanolamide analogue, reduces chronic inflammation in a carrageenin-granuloma model in rats. J Cell Mol Med. 2009 Jun;13(6):1086-95. doi: 10.1111/j.1582-4934.2008.00353.x. PubMed PMID: 18429935; PubMed Central PMCID: PMC4496105.

8: Abramo F, Salluzzi D, Leotta R, Auxilia S, Noli C, Miolo A, Mantis P, Lloyd DH. Mast cell morphometry and densitometry in experimental skin wounds treated with a gel containing adelmidrol: a placebo controlled study. Wounds. 2008 Jun;20(6):149-57. PubMed PMID: 25942520.

9: Pulvirenti N, Nasca MR, Micali G. Topical adelmidrol 2% emulsion, a novel aliamide, in the treatment of mild atopic dermatitis in pediatric subjects: a pilot study. Acta Dermatovenerol Croat. 2007;15(2):80-3. PubMed PMID: 17631786.

10: Noli C, Miolo A. The role of mast cells in the early stages of wound healing. Int Wound J. 2010 Dec;7(6):540. doi: 10.1111/j.1742-481X.2010.00719.x. PubMed PMID: 21073684.

11: Bonello D, Squarzoni P. Effect of a mucoadhesive gel and dental scaling on gingivitis in dogs. J Vet Dent. 2008 Mar;25(1):28-32. PubMed PMID: 18512623.