L-372662

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 532060

CAS#: 162045-26-3

Description: L-372662 is bioactive chemical.


Price and Availability

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Price

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L-372662 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 532060
Name: L-372662
CAS#: 162045-26-3
Chemical Formula: C33H38N4O6
Exact Mass: 586.2791
Molecular Weight: 586.69
Elemental Analysis: C, 67.56; H, 6.53; N, 9.55; O, 16.36


Synonym: L-372662; L 372662; L372662.

IUPAC/Chemical Name: 1-[1-[2-methoxy-4-[1-[(2-methyl-1-oxidopyridin-1-ium-3-yl)methyl]piperidin-4-yl]oxybenzoyl]piperidin-4-yl]-4H-3,1-benzoxazin-2-one

InChi Key: SKWSXDUHUVMPBT-UHFFFAOYSA-N

InChi Code: InChI=1S/C33H38N4O6/c1-23-24(7-5-15-36(23)40)21-34-16-13-27(14-17-34)43-28-9-10-29(31(20-28)41-2)32(38)35-18-11-26(12-19-35)37-30-8-4-3-6-25(30)22-42-33(37)39/h3-10,15,20,26-27H,11-14,16-19,21-22H2,1-2H3

SMILES Code: O=C1N(C2CCN(C(C3=CC=C(OC4CCN(CC5=C(C)[N+]([O-])=CC=C5)CC4)C=C3OC)=O)CC2)C6=CC=CC=C6CO1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: de Wit NC, Heck AJ, Thornton S. The effect of oxytocin and an oxytocin antagonist on the human myometrial proteome. Reprod Sci. 2010 Jan;17(1):40-6. doi: 10.1177/1933719109345287. PubMed PMID: 19767541.

2: Hawtin SR, Ha SN, Pettibone DJ, Wheatley M. A Gly/Ala switch contributes to high affinity binding of benzoxazinone-based non-peptide oxytocin receptor antagonists. FEBS Lett. 2005 Jan 17;579(2):349-56. PubMed PMID: 15642343.

3: Williams PD, Bock MG, Evans BE, Freidinger RM, Pettibone DJ. Progress in the development of oxytocin antagonists for use in preterm labor. Adv Exp Med Biol. 1998;449:473-9. PubMed PMID: 10026841.

4: Bell IM, Erb JM, Freidinger RM, Gallicchio SN, Guare JP, Guidotti MT, Halpin RA, Hobbs DW, Homnick CF, Kuo MS, Lis EV, Mathre DJ, Michelson SR, Pawluczyk JM, Pettibone DJ, Reiss DR, Vickers S, Williams PD, Woyden CJ. Development of orally active oxytocin antagonists: studies on 1-(1-[4-[1-(2-methyl-1-oxidopyridin-3-ylmethyl)piperidin-4-yloxy]-2- methoxybenzoyl]piperidin-4-yl)-1,4-dihydrobenz[d][1,3]oxazin-2-one (L-372,662) and related pyridines. J Med Chem. 1998 Jun 4;41(12):2146-63. PubMed PMID: 9622556.