Blarcamesine

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 529101

CAS#: 195615-83-9 (free base)

Description: Blarcamesine, also known as AVex-73 and AE-37, is a muscarinic M1 agonist potentially for the treatment of Alzheimer's disease. It is an σ receptor ligand.


Chemical Structure

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Blarcamesine
CAS# 195615-83-9 (free base)

Theoretical Analysis

MedKoo Cat#: 529101
Name: Blarcamesine
CAS#: 195615-83-9 (free base)
Chemical Formula: C19H23NO
Exact Mass: 281.18
Molecular Weight: 281.400
Elemental Analysis: C, 81.10; H, 8.24; N, 4.98; O, 5.69

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Related CAS #: 195615-83-9 (free base)   195615-84-0 (HCl)  

Synonym: AE-37; AVex-73; Anavex-2-73; Anavex-273; AE37; AVex73; Anavex273; AE 37; AVex 73; Anavex 2 73; Anavex 273; Blarcamesine

IUPAC/Chemical Name: (R)-1-(2,2-diphenyltetrahydrofuran-3-yl)-N,N-dimethylmethanamine

InChi Key: BOTHKNZTGGXFEQ-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H23NO/c1-20(2)15-18-13-14-21-19(18,16-9-5-3-6-10-16)17-11-7-4-8-12-17/h3-12,18H,13-15H2,1-2H3

SMILES Code: CN(C)CC1C(C2=CC=CC=C2)(C3=CC=CC=C3)OCC1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 281.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Matsueda S, Gao H, Efferson CL, Tsuda N, Ishiyama S, Li Y, Ioannides MG, Fisk B, Peoples GE, Ioannides CG. N-terminally LRMK-linked HER-2 peptides, AE-37 [p776(774-788)] and AE-47 [Ava-F7(776-788)], aid differentiation of E75-TCR+CD8+ cells to perforin-positive cells. Anticancer Res. 2009 Jul;29(7):2427-35. PubMed PMID: 19596910.

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