KGP94

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 532000

CAS#: 1131456-28-4

Description: KGP94 is cysteine protease Cathepsin L inhibitor(CTSL).

Chemical Structure

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KGP94
CAS# 1131456-28-4
Instruction

Theoretical Analysis

MedKoo Cat#: 532000
Name: KGP94
CAS#: 1131456-28-4
Chemical Formula: C14H12BrN3OS
Exact Mass: 348.99
Molecular Weight: 350.230
Elemental Analysis: C, 48.01; H, 3.45; Br, 22.81; N, 12.00; O, 4.57; S, 9.15

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: KGP94; KGP 94; KGP-94.

IUPAC/Chemical Name: [(E)-[(3-bromophenyl)(3-hydroxyphenyl)methylidene]amino]thiourea

InChi Key: ZDBKSZKTCPOBFR-LGMDPLHJSA-N

InChi Code: InChI=1S/C14H12BrN3OS/c15-11-5-1-3-9(7-11)13(17-18-14(16)20)10-4-2-6-12(19)8-10/h1-8,19H,(H3,16,18,20)/b17-13-

SMILES Code: S=C(N)N/N=C(C1=CC=CC(Br)=C1)\C2=CC=CC(O)=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 350.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Parker EN, Odutola SO, Wang Y, Strecker TE, Mukherjee R, Shi Z, Chaplin DJ, Trawick ML, Pinney KG. Synthesis and biological evaluation of a water-soluble phosphate prodrug salt and structural analogues of KGP94, a lead inhibitor of cathepsin L. Bioorg Med Chem Lett. 2017 Mar 1;27(5):1304-1310. doi: 10.1016/j.bmcl.2016.12.039. PubMed PMID: 28117205.

2: Sudhan DR, Rabaglino MB, Wood CE, Siemann DW. Cathepsin L in tumor angiogenesis and its therapeutic intervention by the small molecule inhibitor KGP94. Clin Exp Metastasis. 2016 Jun;33(5):461-73. doi: 10.1007/s10585-016-9790-1. PubMed PMID: 27055649.

3: Sudhan DR, Pampo C, Rice L, Siemann DW. Cathepsin L inactivation leads to multimodal inhibition of prostate cancer cell dissemination in a preclinical bone metastasis model. Int J Cancer. 2016 Jun 1;138(11):2665-77. doi: 10.1002/ijc.29992. PubMed PMID: 26757413; PubMed Central PMCID: PMC4805507.

4: Sudhan DR, Siemann DW. Cathepsin L inhibition by the small molecule KGP94 suppresses tumor microenvironment enhanced metastasis associated cell functions of prostate and breast cancer cells. Clin Exp Metastasis. 2013 Oct;30(7):891-902. doi: 10.1007/s10585-013-9590-9. PubMed PMID: 23748470; PubMed Central PMCID: PMC3823630.

5: Chavarria GE, Horsman MR, Arispe WM, Kumar GD, Chen SE, Strecker TE, Parker EN, Chaplin DJ, Pinney KG, Trawick ML. Initial evaluation of the antitumour activity of KGP94, a functionalized benzophenone thiosemicarbazone inhibitor of cathepsin L. Eur J Med Chem. 2012 Dec;58:568-72. doi: 10.1016/j.ejmech.2012.10.039. PubMed PMID: 23168380.