KB-141

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 531994

CAS#: 219691-94-8

Description: KB-141 is thyroid hormone receptor agonist.


Price and Availability

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Price

Size
Price

Size
Price

KB-141 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 531994
Name: KB-141
CAS#: 219691-94-8
Chemical Formula: C17H16Cl2O4
Exact Mass: 354.0426
Molecular Weight: 355.21
Elemental Analysis: C, 57.48; H, 4.54; Cl, 19.96; O, 18.02


Synonym: KB-141; KB 141; KB141.

IUPAC/Chemical Name: 2-[3,5-dichloro-4-(4-hydroxy-3-propan-2-ylphenoxy)phenyl]acetic acid

InChi Key: OZYQIQVPUZANTM-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H16Cl2O4/c1-9(2)12-8-11(3-4-15(12)20)23-17-13(18)5-10(6-14(17)19)7-16(21)22/h3-6,8-9,20H,7H2,1-2H3,(H,21,22)

SMILES Code: O=C(O)CC1=CC(Cl)=C(OC2=CC=C(O)C(C(C)C)=C2)C(Cl)=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Shi C, Meng Q, Wood DW. Analysis of the roles of mutations in thyroid hormone receptor-β by a bacterial biosensor system. J Mol Endocrinol. 2014 Jan 8;52(1):55-66. doi: 10.1530/JME-13-0108. PubMed PMID: 24174637.

2: Tóth G, Noszál B. [Thyroid hormones and their precursors I. Biochemical properties]. Acta Pharm Hung. 2013;83(2):35-45. Review. Hungarian. PubMed PMID: 23926648.

3: Gierach I, Li J, Wu WY, Grover GJ, Wood DW. Bacterial biosensors for screening isoform-selective ligands for human thyroid receptors α-1 and β-1. FEBS Open Bio. 2012 Aug 15;2:247-53. doi: 10.1016/j.fob.2012.08.002. PubMed PMID: 23667826; PubMed Central PMCID: PMC3642162.

4: Tancevski I, Eller P, Patsch JR, Ritsch A. The resurgence of thyromimetics as lipid-modifying agents. Curr Opin Investig Drugs. 2009 Sep;10(9):912-8. Review. PubMed PMID: 19705333; PubMed Central PMCID: PMC2993058.

5: Cable EE, Finn PD, Stebbins JW, Hou J, Ito BR, van Poelje PD, Linemeyer DL, Erion MD. Reduction of hepatic steatosis in rats and mice after treatment with a liver-targeted thyroid hormone receptor agonist. Hepatology. 2009 Feb;49(2):407-17. doi: 10.1002/hep.22572. PubMed PMID: 19072834.