KB-130015

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 531993

CAS#: 147030-48-6

Description: KB-130015 is a novel activator of hERG1 potassium channels, blocking native and recombinant hERG1 channels at high voltages.


Price and Availability

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Price

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Price

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KB-130015 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 531993
Name: KB-130015
CAS#: 147030-48-6
Chemical Formula: C18H14I2O4
Exact Mass: 547.8981
Molecular Weight: 548.11
Elemental Analysis: C, 39.44; H, 2.57; I, 46.31; O, 11.68


Synonym: KB-130015; KB 130015; KB130015.

IUPAC/Chemical Name: 2-[2,6-diiodo-4-[(2-methyl-1-benzofuran-3-yl)methyl]phenoxy]acetic acid

InChi Key: OLIKCJUMYWSDIV-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H14I2O4/c1-10-13(12-4-2-3-5-16(12)24-10)6-11-7-14(19)18(15(20)8-11)23-9-17(21)22/h2-5,7-8H,6,9H2,1H3,(H,21,22)

SMILES Code: O=C(O)COC1=C(I)C=C(CC2=C(C)OC3=C2C=CC=C3)C=C1I


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Gessner G, Macianskiene R, Starkus JG, Schönherr R, Heinemann SH. The amiodarone derivative KB130015 activates hERG1 potassium channels via a novel mechanism. Eur J Pharmacol. 2010 Apr 25;632(1-3):52-9. doi: 10.1016/j.ejphar.2010.01.010. PubMed PMID: 20097192; PubMed Central PMCID: PMC2835770.

2: Borchard R, van Bracht M, Wickenbrock I, Prull MW, Pott L, Trappe HJ. [Inhibition of the muscarinic potassium current by KB130015, a new antiarrhythmic agent to treat atrial fibrillation]. Med Klin (Munich). 2005 Nov 15;100(11):697-703. German. PubMed PMID: 16328176.