SAD-448

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 528211

CAS#: 581106-09-4

Description: SAD-448 is a cannabinoid receptor type 1 (CB1) agonist potentially for the treatment of ocular hypertension and chronic pain. SAD-448 controls spasticity via action on the peripheral nerve CB1 receptor.


Price and Availability

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SAD-448 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 528211
Name: SAD-448
CAS#: 581106-09-4
Chemical Formula: C24H28N4O8S
Exact Mass: 532.1628
Molecular Weight: 532.568
Elemental Analysis: C, 54.13; H, 5.30; N, 10.52; O, 24.03; S, 6.02


Synonym: SAD-448; SAD 448; SAD448

IUPAC/Chemical Name: ethyl 2-((((2-hydroxyethyl)carbamoyl)oxy)methyl)-5,7-dimethyl-3-(2-(N-methylsulfamoyl)phenyl)-4-oxo-3,4-dihydroquinazoline-6-carboxylate

InChi Key: PMBUDILHPXTDNY-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H28N4O8S/c1-5-35-23(31)20-14(2)12-16-21(15(20)3)22(30)28(19(27-16)13-36-24(32)26-10-11-29)17-8-6-7-9-18(17)37(33,34)25-4/h6-9,12,25,29H,5,10-11,13H2,1-4H3,(H,26,32)

SMILES Code: O=C(C1=C(C)C2=C(N=C(COC(NCCO)=O)N(C3=CC=CC=C3S(=O)(NC)=O)C2=O)C=C1C)OCC


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Pryce G, Visintin C, Ramagopalan SV, Al-Izki S, De Faveri LE, Nuamah RA, Mein CA, Montpetit A, Hardcastle AJ, Kooij G, de Vries HE, Amor S, Thomas SA, Ledent C, Marsicano G, Lutz B, Thompson AJ, Selwood DL, Giovannoni G, Baker D. Control of spasticity in a multiple sclerosis model using central nervous system-excluded CB1 cannabinoid receptor agonists. FASEB J. 2014 Jan;28(1):117-30. doi: 10.1096/fj.13-239442. PubMed PMID: 24121462.