VCH-286

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 528210

CAS#: 891824-47-8

Description: VCH-286 is a C-C chemokine receptor type 5 (CCR5) receptor antagonist potentially for the treatment of HIV infection. Although VCH-286 used alone had highly inhibitory activity, paired combinations with different drug classes led to synergistic or additive interactions. However, combinations with other CCR5 inhibitors led to effects ranging from synergy to antagonism.

Chemical Structure

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VCH-286
CAS# 891824-47-8
Instruction

Theoretical Analysis

MedKoo Cat#: 528210
Name: VCH-286
CAS#: 891824-47-8
Chemical Formula: C34H50F2N4O3
Exact Mass: 600.39
Molecular Weight: 600.796
Elemental Analysis: C, 67.97; H, 8.39; F, 6.32; N, 9.33; O, 7.99

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: VCH-286; VCH 286; VCH286

IUPAC/Chemical Name: 4,4-difluoro-N-((S)-3-((1R,3R,5S)-3'-isopropyl-2'-oxo-1'-((tetrahydro-2H-pyran-4-yl)methyl)-8-azaspiro[bicyclo[3.2.1]octane-3,4'-imidazolidin]-8-yl)-1-phenylpropyl)cyclohexane-1-carboxamide

InChi Key: YZGXEGUSPLSQOJ-MJOCGKAJSA-N

InChi Code: InChI=1S/C34H50F2N4O3/c1-24(2)40-32(42)38(22-25-13-18-43-19-14-25)23-33(40)20-28-8-9-29(21-33)39(28)17-12-30(26-6-4-3-5-7-26)37-31(41)27-10-15-34(35,36)16-11-27/h3-7,24-25,27-30H,8-23H2,1-2H3,(H,37,41)/t28-,29+,30-,33-/m0/s1

SMILES Code: O=C(C1CCC(F)(F)CC1)N[C@H](C2=CC=CC=C2)CCN3[C@H]4C[C@](N(C(C)C)C5=O)(CN5CC6CCOCC6)C[C@@H]3CC4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 600.80 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Asin-Milan O, Sylla M, El-Far M, Belanger-Jasmin G, Haidara A, Blackburn J, Chamberland A, Tremblay CL. Synergistic combinations of the CCR5 inhibitor VCH-286 with other classes of HIV-1 inhibitors. Antimicrob Agents Chemother. 2014 Dec;58(12):7565-9. doi: 10.1128/AAC.03630-14. PubMed PMID: 25267674; PubMed Central PMCID: PMC4249518.