BI-11634

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 528206

CAS#: 1622159-00-5

Description: BI-11634 is a factor Xa inhibitor potentially for the treatment of cardiovascular disorders. The metabolism of BI-11634 in human liver microsomes was inhibited by ketoconazole and quinidine, well-accepted specific inhibitors of CYP3A4 and CYP2D6, respectively. In contrast, BI-11634 metabolism was exclusively mediated by rCYP3A4. Additional studies confirmed that BI-11634 was metabolized by CYP3A4 to form one major metabolite and this reaction was inhibited by quinidine.


Price and Availability

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BI-11634 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 528206
Name: BI-11634
CAS#: 1622159-00-5
Chemical Formula: C22H22ClN4NaO4
Exact Mass:
Molecular Weight: 464.8818
Elemental Analysis: C, 56.84; H, 4.77; Cl, 7.63; N, 12.05; Na, 4.95; O, 13.77


Synonym: BI-11634; BI 11634; BI11634

IUPAC/Chemical Name: sodium (R)-(1-(6-chloro-1H-benzo[d]imidazol-2-yl)-2-methoxyethyl)(3-methyl-4-(3-oxomorpholino)benzoyl)amide

InChi Key: OJSUHLVJVGHFKW-FERBBOLQSA-M

InChi Code: InChI=1S/C22H23ClN4O4.Na/c1-13-9-14(3-6-19(13)27-7-8-31-12-20(27)28)22(29)26-18(11-30-2)21-24-16-5-4-15(23)10-17(16)25-21;/h3-6,9-10,18H,7-8,11-12H2,1-2H3,(H2,24,25,26,29);/q;+1/p-1/t18-;/m0./s1

SMILES Code: O=C([N-][C@H](C1=NC2=CC=C(Cl)C=C2N1)COC)C3=CC=C(N4C(COCC4)=O)C(C)=C3.[Na+]


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Mathur A, Tweedie DJ, Maw HH, Li Y. Unexpected interaction between CYP3A4 and BI 11634: is BI 11634 interacting with CYP3A4 similar to nifedipine? Drug Metabol Drug Interact. 2013;28(4):239-46. doi: 10.1515/dmdi-2013-0044. PubMed PMID: 24166670.