JNJ16259685

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 531980

CAS#: 409345-29-5

Description: JNJ16259685 is a potent, non-competitive mGlu1 antagonist (Ki = 0.34 nM). JNJ16259685 inhibits glutamate-induced Ca2+ response at the human mGlu1 receptor with an IC50 value of 0.55 nM. JNJ16259685 is selective over mGlu5 (> 400-fold) and displays no activity at mGlu2, mGlu3, mGlu4, mGlu6, AMPA or NMDA receptors (IC50 > 10 μM).


Price and Availability

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JNJ16259685 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 531980
Name: JNJ16259685
CAS#: 409345-29-5
Chemical Formula: C20H23NO3
Exact Mass: 325.1678
Molecular Weight: 325.41
Elemental Analysis: C, 73.82; H, 7.12; N, 4.30; O, 14.75


Synonym: JNJ16259685; JNJ 16259685; JNJ-16259685.

IUPAC/Chemical Name: (3,4-dihydro-2H-pyrano[2,3-b]quinolin-7-yl)(4-methoxycyclohexyl)methanone

InChi Key: QOTAQTRFJWLFCR-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H23NO3/c1-23-17-7-4-13(5-8-17)19(22)14-6-9-18-16(11-14)12-15-3-2-10-24-20(15)21-18/h6,9,11-13,17H,2-5,7-8,10H2,1H3

SMILES Code: O=C(C1=CC=C2N=C3C(CCCO3)=CC2=C1)C4CCC(OC)CC4


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Hodgson RA, Hyde LA, Guthrie DH, Cohen-Williams ME, Leach PT, Kazdoba TM, Bleickardt CJ, Lu SX, Parker EM, Varty GB. Characterization of the selective mGluR1 antagonist, JNJ16259685, in rodent models of movement and coordination. Pharmacol Biochem Behav. 2011 Apr;98(2):181-7. doi: 10.1016/j.pbb.2010.11.018. PubMed PMID: 21122808.

2: Navarro JF, De Castro V, Martín-López M. JNJ16259685, a selective mGlu1 antagonist, suppresses isolation-induced aggression in male mice. Eur J Pharmacol. 2008 May 31;586(1-3):217-20. doi: 10.1016/j.ejphar.2008.02.070. PubMed PMID: 18367165.

3: Fukunaga I, Yeo CH, Batchelor AM. Potent and specific action of the mGlu1 antagonists YM-298198 and JNJ16259685 on synaptic transmission in rat cerebellar slices. Br J Pharmacol. 2007 Jul;151(6):870-6. PubMed PMID: 17502847; PubMed Central PMCID: PMC2014124.

4: Lavreysen H, Wouters R, Bischoff F, Nóbrega Pereira S, Langlois X, Blokland S, Somers M, Dillen L, Lesage AS. JNJ16259685, a highly potent, selective and systemically active mGlu1 receptor antagonist. Neuropharmacology. 2004 Dec;47(7):961-72. PubMed PMID: 15555631.