OPC-28326 HCl hydrate

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MedKoo CAT#: 529326

CAS#: 167626-17-7 (OPC-28326 HCl hydrate)

Description: OPC-28326 is an adrenergic receptor antagonist potentially for the treatment of intermittent claudication and Raynaud's Syndrome

Chemical Structure

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OPC-28326 HCl hydrate
CAS# 167626-17-7 (OPC-28326 HCl hydrate)
Instruction

Theoretical Analysis

MedKoo Cat#: 529326
Name: OPC-28326 HCl hydrate
CAS#: 167626-17-7 (OPC-28326 HCl hydrate)
Chemical Formula: C26H38ClN3O3
Exact Mass: 475.26
Molecular Weight: 476.058
Elemental Analysis: C, 65.60; H, 8.05; Cl, 7.45; N, 8.83; O, 10.08

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 478946-89-3 (OPC-28326 free)  

Synonym: OPC-28326; OPC28326; OPC 28326

IUPAC/Chemical Name: N-(2,6-dimethyl-4-(4-(methyl(phenethyl)amino)piperidine-1-carbonyl)phenyl)propionamide hydrochloride hydrate

InChi Key: QRNMKZJPTYRAIL-UHFFFAOYSA-N

InChi Code: InChI=1S/C26H35N3O2.ClH.H2O/c1-5-24(30)27-25-19(2)17-22(18-20(25)3)26(31)29-15-12-23(13-16-29)28(4)14-11-21-9-7-6-8-10-21;;/h6-10,17-18,23H,5,11-16H2,1-4H3,(H,27,30);1H;1H2

SMILES Code: CCC(NC1=C(C)C=C(C(N2CCC(N(C)CCC3=CC=CC=C3)CC2)=O)C=C1C)=O.[H]Cl.[H]O[H]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 476.06 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Ogino A, Takemura G, Hashimoto A, Kanamori H, Okada H, Nakagawa M, Tsujimoto A, Goto K, Kawasaki M, Nagashima K, Miyakoda G, Fujiwara T, Yabuuchi Y, Fujiwara H, Minatoguchi S. OPC-28326, a selective peripheral vasodilator with angiogenic activity, mitigates postinfarction cardiac remodeling. Am J Physiol Heart Circ Physiol. 2015 Jul 1;309(1):H213-21. doi: 10.1152/ajpheart.00062.2015. PubMed PMID: 25910803.

2: Wise RA, Wigley FM, White B, Leatherman G, Zhong J, Krasa H, Kambayashi J, Orlandi C, Czerwiec FS. Efficacy and tolerability of a selective alpha(2C)-adrenergic receptor blocker in recovery from cold-induced vasospasm in scleroderma patients: a single-center, double-blind, placebo-controlled, randomized crossover study. Arthritis Rheum. 2004 Dec;50(12):3994-4001. PubMed PMID: 15593189.

3: Orito K, Imaizumi T, Yoshida K, Kishi M, Fujiki H, Mori T. Effect of oral OPC-28326, a selective femoral arterial vasodilator, on hindlimb subcutaneous tissue temperature in conscious dogs under buprenorphine sedation. Jpn J Pharmacol. 2002 Jan;88(1):119-22. PubMed PMID: 11855671.

4: Sumi M, Sata M, Hashimoto A, Imaizumi T, Yanaga K, Ohki T, Mori T, Nagai R. OPC-28326, a selective femoral arterial vasodilator, augments ischemia induced angiogenesis. Biomed Pharmacother. 2007 May;61(4):209-15. PubMed PMID: 17223008.

5: Orito K, Kishi M, Imaizumi T, Nakazawa T, Hashimoto A, Mori T, Kambe T. alpha(2)-adrenoceptor antagonist properties of OPC-28326, a novel selective peripheral vasodilator. Br J Pharmacol. 2001 Oct;134(4):763-70. PubMed PMID: 11606316; PubMed Central PMCID: PMC1573002.

6: Orito K, Imaizumi T, Yoshida K, Fujiki H, Kishi M, Teramoto S, Tanaka M, Shimizu H, Tominaga M, Kimura Y, Kambayashi J, Mori T. Mechanisms of action of OPC-28326, a selective hindlimb vasodilator. J Pharmacol Exp Ther. 1999 Nov;291(2):604-11. PubMed PMID: 10525078.

7: Sun B, Lockyer S, Li J, Chen R, Yoshitake M, Kambayashi JI. OPC-28326, a selective femoral vasodilator, is an alpha2C-adrenoceptor-selective antagonist. J Pharmacol Exp Ther. 2001 Nov;299(2):652-8. PubMed PMID: 11602678.

8: Mehrotra S, Gupta S, Garrelds IM, Villalón CM, Saxena PR, Bogers AJ, Maassenvandenbrink A. Effects of current and prospective antimigraine drugs on the porcine isolated meningeal artery. Naunyn Schmiedebergs Arch Pharmacol. 2006 Dec;374(3):163-75. PubMed PMID: 17103145.

9: Bayés M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2003 Dec;25(10):831-55. PubMed PMID: 14735233.

10: Fukui D, Yang XP, Chiba S. Neurogenic double-peaked vasoconstriction of human gastroepiploic artery is mediated by both alpha1- and alpha2-adrenoceptors. Br J Pharmacol. 2005 Mar;144(6):737-42. PubMed PMID: 15685216; PubMed Central PMCID: PMC1576054.

11: Bayés M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2004 Jan-Feb;26(1):53-84. Review. PubMed PMID: 14988742.

12: Robins P. Japanese Pharmacological Society--77th Annual Meeting. Part I. 8-10 March 2004, Osaka, Japan. IDrugs. 2004 Apr;7(4):295-7. PubMed PMID: 15057628.