ICI 204448

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 531967

CAS#: 125190-72-9

Description: ICI 204448 is a potent and peripherally selective κ-opioid agonist, with possible uses in the treatment of heart attack as well as anti-itching effects.


Price and Availability

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ICI 204448 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 531967
Name: ICI 204448
CAS#: 125190-72-9
Chemical Formula: C23H26Cl2N2O4
Exact Mass: 464.127
Molecular Weight: 465.37
Elemental Analysis: C, 59.36; H, 5.63; Cl, 15.24; N, 6.02; O, 13.75


Synonym: ICI 204448; ICI204448; ICI-204448.

IUPAC/Chemical Name: 2-[3-[1-[[2-(3,4-dichlorophenyl)acetyl]-methylamino]-2-pyrrolidin-1-ylethyl]phenoxy]acetic acid

InChi Key: JKYJSFISYHSNOE-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H26Cl2N2O4/c1-26(22(28)12-16-7-8-19(24)20(25)11-16)21(14-27-9-2-3-10-27)17-5-4-6-18(13-17)31-15-23(29)30/h4-8,11,13,21H,2-3,9-10,12,14-15H2,1H3,(H,29,30)

SMILES Code: O=C(O)COC1=CC=CC(C(N(C(CC2=CC=C(Cl)C(Cl)=C2)=O)C)CN3CCCC3)=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Caram-Salas NL, Reyes-García G, Bartoszyk GD, Araiza-Saldaña CI, Ambriz-Tututi M, Rocha-González HI, Arreola-Espino R, Cruz SL, Granados-Soto V. Subcutaneous, intrathecal and periaqueductal grey administration of asimadoline and ICI-204448 reduces tactile allodynia in the rat. Eur J Pharmacol. 2007 Nov 14;573(1-3):75-83. PubMed PMID: 17643411.

2: Rawls SM, Ding Z, Gray AM, Cowan A. Peripheral kappa-opioid agonist, ICI 204448, evokes hypothermia in cold-exposed rats. Pharmacology. 2005 May;74(2):79-83. PubMed PMID: 15687734.

3: Keïta H, Kayser V, Guilbaud G. Antinociceptive effect of a kappa-opioid receptor agonist that minimally crosses the blood-brain barrier (ICI 204448) in a rat model of mononeuropathy. Eur J Pharmacol. 1995 Apr 24;277(2-3):275-80. PubMed PMID: 7493620.

4: Shaw JS, Carroll JA, Alcock P, Main BG. ICI 204448: a kappa-opioid agonist with limited access to the CNS. Br J Pharmacol. 1989 Apr;96(4):986-92. PubMed PMID: 2568146; PubMed Central PMCID: PMC1854424.