ICI 192605
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 531966

CAS#: 117621-64-4

Description: ICI 192605 is a potent thromboxane A2 receptor (TP receptor) antagonist.


Price and Availability

Size
Price

5mg
USD 230
Size
Price

25g
USD 580
Size
Price

ICI 192605, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 531966
Name: ICI 192605
CAS#: 117621-64-4
Chemical Formula: C22H23ClO5
Exact Mass: 402.1234
Molecular Weight: 402.87
Elemental Analysis: C, 65.59; H, 5.75; Cl, 8.80; O, 19.86


Synonym: ICI 192605 ; ICI192605; ICI-192605 .

IUPAC/Chemical Name: (E)-6-[(2S,4S,5R)-2-(2-chlorophenyl)-4-(2-hydroxyphenyl)-1,3-dioxan-5-yl]hex-4-enoic acid

InChi Key: WHUIENZXNGAHQI-BNGKFCBFSA-N

InChi Code: InChI=1S/C22H23ClO5/c23-18-11-6-4-9-16(18)22-27-14-15(8-2-1-3-13-20(25)26)21(28-22)17-10-5-7-12-19(17)24/h1-2,4-7,9-12,15,21-22,24H,3,8,13-14H2,(H,25,26)/b2-1+/t15-,21+,22+/m1/s1

SMILES Code: O=C(O)CC/C=C/C[C@H]1[C@@H](C2=CC=CC=C2O)O[C@@H](C3=CC=CC=C3Cl)OC1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Brown GR, Foubister AJ, Hudson JA. Improved synthetic routes to the novel thromboxane receptor antagonist ICI 192605: activity of synthetic 1,3-dioxane intermediates. J Pharm Pharmacol. 1990 Jan;42(1):53-5. PubMed PMID: 1969951.

2: Brewster AG, Brown GR, Foubister AJ, Jessup R, Smithers MJ. The synthesis of a novel thromboxane receptor antagonist 4(Z)-6-(2-o-chlorophenyl-4-o-hydroxyphenyl-1,3-dioxan-cis-5-yl) hexenoic acid ICI 192605. Prostaglandins. 1988 Aug;36(2):173-8. PubMed PMID: 2973084.