BI-1467335 HCl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 527808

CAS#: 1478364-68-9 (HCl)

Description: BI-1467335, also known as PXS-4728A, is a SSAO/VAP inhibitor potentially for the treatment of non-alcoholic steatohepatitis. VAP-1/SSAO contributes to the migration of neutrophils during acute lung inflammation, pulmonary infection and airway hyperractivity. Selective VAP-1/SSAO inhibition by PXS-4728A diminished leukocyte rolling and adherence induced by CXCL1/KC. Inhibition of VAP-1/SSAO also dampened the migration of neutrophils to the lungs in response to LPS, Klebsiella pneumoniae lung infection and CLP induced sepsis; whilst still allowing for normal neutrophil defense function, resulting in increased survival.


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BI-1467335 HCl is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 527808
Name: BI-1467335 HCl
CAS#: 1478364-68-9 (HCl)
Chemical Formula: C15H22ClFN2O2
Exact Mass:
Molecular Weight: 316.8014
Elemental Analysis: C, 56.87; H, 7.00; Cl, 11.19; F, 6.00; N, 8.84; O, 10.10


Related CAS #: 1478364-68-9 (HCl)   1478364-40-7 (free base)    

Synonym: PXS-4728A; PXS4728A; PXS 4728A; BI-1467335; BI 1467335; BI1467335; BI-1467335 HCl; BI-1467335 hydrochloride

IUPAC/Chemical Name: (E)-4-((2-(aminomethyl)-3-fluoroallyl)oxy)-N-(tert-butyl)benzamide hydrochloride

InChi Key: AEMZEDNMNLIDSL-YGCVIUNWSA-N

InChi Code: InChI=1S/C15H21FN2O2.ClH/c1-15(2,3)18-14(19)12-4-6-13(7-5-12)20-10-11(8-16)9-17;/h4-8H,9-10,17H2,1-3H3,(H,18,19);1H/b11-8+;

SMILES Code: O=C(NC(C)(C)C)C1=CC=C(OC/C(CN)=C/F)C=C1.[H]Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Schilter HC, Collison A, Russo RC, Foot JS, Yow TT, Vieira AT, Tavares LD, Mattes J, Teixeira MM, Jarolimek W. Effects of an anti-inflammatory VAP-1/SSAO inhibitor, PXS-4728A, on pulmonary neutrophil migration. Respir Res. 2015 Mar 20;16:42. doi: 10.1186/s12931-015-0200-z. PubMed PMID: 25889951; PubMed Central PMCID: PMC4389443.

2: Jarnicki AG, Schilter H, Liu G, Wheeldon K, Essilfie AT, Foot JS, Yow TT, Jarolimek W, Hansbro PM. The inhibitor of semicarbazide-sensitive amine oxidase, PXS-4728A, ameliorates key features of chronic obstructive pulmonary disease in a mouse model. Br J Pharmacol. 2016 Nov;173(22):3161-3175. doi: 10.1111/bph.13573. PubMed PMID: 27495192; PubMed Central PMCID: PMC5071557.

3: Katagiri D, Hamasaki Y, Doi K, Negishi K, Sugaya T, Nangaku M, Noiri E. Interstitial renal fibrosis due to multiple cisplatin treatments is ameliorated by semicarbazide-sensitive amine oxidase inhibition. Kidney Int. 2016 Feb;89(2):374-85. PubMed PMID: 26535996.