Becocalcidiol

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 529308

CAS#: 524067-21-8

Description: Becocalcidiol, also known as QRX-101, DP-006 and COL-121, is a vitamin D analog potentially for the treatment of psoriasis.


Price and Availability

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Becocalcidiol is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 529308
Name: Becocalcidiol
CAS#: 524067-21-8
Chemical Formula: C23H36O2
Exact Mass: 344.2715
Molecular Weight: 344.53
Elemental Analysis: C, 80.18; H, 10.53; O, 9.29


Synonym: QRX-101; DP-006; COL-121; QRX101; DP006; COL121; QRX 101; DP 006; COL 121; Becocalcidiol

IUPAC/Chemical Name: (1R,3R,E)-4-(2-((1R,3aS,7aR,E)-1-((S)-sec-butyl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-2-methylenecyclohexane-1,3-diol

InChi Key: LIPXYRRLVFIGDM-GKBMBEDOSA-N

InChi Code: InChI=1S/C23H36O2/c1-5-15(2)19-11-12-20-17(7-6-14-23(19,20)4)8-9-18-10-13-21(24)16(3)22(18)25/h8-9,15,19-22,24-25H,3,5-7,10-14H2,1-2,4H3/b17-8+,18-9+/t15-,19+,20-,21+,22-,23+/m0/s1

SMILES Code: O[C@H]1C([C@H](O)/C(CC1)=C/C=C2[C@]3([H])CC[C@H]([C@H](CC)C)[C@@]3(C)CCC/2)=C


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Helfrich YR, Kang S, Hamilton TA, Voorhees JJ. Topical becocalcidiol for the treatment of psoriasis vulgaris: a randomized, placebo-controlled, double-blind, multicentre study. Br J Dermatol. 2007 Aug;157(2):369-74. PubMed PMID: 17596167.

2: Mason AR, Mason J, Cork M, Dooley G, Hancock H. Topical treatments for chronic plaque psoriasis. Cochrane Database Syst Rev. 2013 Mar 28;(3):CD005028. doi: 10.1002/14651858.CD005028.pub3. Review. PubMed PMID: 23543539.

3: Bayés M, Rabasseda X. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2008 Jan-Feb;30(1):67-99. PubMed PMID: 18389098.