YKL-04-085

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530516

CAS#: Unknown

Description: YKL-04-085 is a potent inhibitor of viral translation and exhibits cellular antiviral activity at 35-fold lower concentrations relative to inhibition of host-cell proliferation. YKL-04-085 demonstrated good inhibition of translation of the DENV2(GVD) reporter replicon in cellulo.


Price and Availability

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YKL-04-085 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 530516
Name: YKL-04-085
CAS#: Unknown
Chemical Formula: C30H29N5O2
Exact Mass: 491.2321
Molecular Weight: 491.595
Elemental Analysis: C, 73.30; H, 5.95; N, 14.25; O, 6.51


Synonym: YKL-04-085; YKL04-085; YKL 04-085; YKL-04085; YKL04085; YKL 04085.

IUPAC/Chemical Name: (E)-4-(dimethylamino)-N-(2-methyl-5-(9-(1-methyl-1H-pyrazol-4-yl)-2-oxobenzo[h]quinolin-1(2H)-yl)phenyl)but-2-enamide

InChi Key: JNHXDBIEQOIKLK-AATRIKPKSA-N

InChi Code: InChI=1S/C30H29N5O2/c1-20-7-13-25(17-27(20)32-28(36)6-5-15-33(2)3)35-29(37)14-12-22-10-8-21-9-11-23(16-26(21)30(22)35)24-18-31-34(4)19-24/h5-14,16-19H,15H2,1-4H3,(H,32,36)/b6-5+

SMILES Code: O=C1N(C2=CC(NC(/C=C/CN(C)C)=O)=C(C=C2)C)C3=C(C=CC4=CC=C(C5=CN(C)N=C5)C=C43)C=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

Structure–Activity Relationship Study of QL47: A Broad-Spectrum Antiviral Agent Yanke LiangMelissanne de WispelaereMargot CarocciQingsong LiuJinhua WangPriscilla L. YangNathanael S. Gray Publication Date (Web): February 3, 2017 (Letter) DOI: 10.1021/acsmedchemlett.7b00008