BF-1

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 527710

CAS#: 518980-66-0

Description: BF-1 is a 5-Hydroxytryptamine receptor 2B (5-HT2B, serotonin receptor 2B) antagonist potentially for the treatment of migraine. BF-1 was tested as potential migraine prophylactic drug by blocking meta-chlorophenylpiperazine, (mCPP) or BW723C86 (5-((thiophen-2-yl)methoxy)-α-methyltryptamine) induced neurogenic dural plasma protein extravasation in a guinea pig model that may resemble a migraine attack.


Price and Availability

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BF-1 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 527710
Name: BF-1
CAS#: 518980-66-0
Chemical Formula: C22H25NO2S
Exact Mass: 367.1606
Molecular Weight: 367.507
Elemental Analysis: C, 71.90; H, 6.86; N, 3.81; O, 8.71; S, 8.72


Synonym: BF-1; BF 1; BF1

IUPAC/Chemical Name: 4-(6-ethoxy-1-methoxy-9H-thioxanthen-9-ylidene)-1-methylpiperidine

InChi Key: ANZVBVKYXOGOQC-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H25NO2S/c1-4-25-16-8-9-17-20(14-16)26-19-7-5-6-18(24-3)22(19)21(17)15-10-12-23(2)13-11-15/h5-9,14H,4,10-13H2,1-3H3

SMILES Code: CN1CC/C(CC1)=C2C3=C(SC4=C\2C=CC(OCC)=C4)C=CC=C3OC


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Schmitz B, Ullmer C, Segelcke D, Gwarek M, Zhu XR, Lübbert H. BF-1--a novel selective 5-HT2B receptor antagonist blocking neurogenic dural plasma protein extravasation in guinea pigs. Eur J Pharmacol. 2015 Mar 15;751:73-80. doi: 10.1016/j.ejphar.2015.01.043. PubMed PMID: 25666387.