EM-523

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 531776

CAS#: 33396-29-1

Description: EM-523 is an erythromycin derivative which is a potent motilin agonist .


Chemical Structure

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EM-523
CAS# 33396-29-1

Theoretical Analysis

MedKoo Cat#: 531776
Name: EM-523
CAS#: 33396-29-1
Chemical Formula: C38H67NO12
Exact Mass: 729.47
Molecular Weight: 729.950
Elemental Analysis: C, 62.53; H, 9.25; N, 1.92; O, 26.30

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: EM-523; EM 523; EM523.

IUPAC/Chemical Name: (1S,2R,3S,4S,5R,8R,9S,10R,11R)-8-ethyl-2-[(2S,3R,4S,6R)-4-(ethyl-methylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-9,10-dihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-1,3,5,9,11,13-hexamethyl-7,15-dioxabicyclo[10.2.1]pentadec-12-en-6-one

InChi Key: UTTLXGDLSXWDJI-OTELOYJSSA-N

InChi Code: InChI=1S/C38H67NO12/c1-14-26-38(11,44)31(41)21(5)29-19(3)17-37(10,51-29)33(50-35-28(40)25(39(12)15-2)16-20(4)46-35)22(6)30(23(7)34(43)48-26)49-27-18-36(9,45-13)32(42)24(8)47-27/h20-28,30-33,35,40-42,44H,14-18H2,1-13H3/t20-,21+,22+,23-,24+,25+,26-,27+,28-,30+,31-,32+,33-,35+,36-,37+,38-/m1/s1

SMILES Code: O=C1[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@H](O)[C@](C)(OC)C2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(CC)C)[C@H]3O)[C@](O4)(C)CC(C)=C4[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)O1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 729.95 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Mizumoto A, Otawa M, Kondo Y, Ito Z, Omura S. [Effect of motilin agonist, EM-523 on gastrointestinal motility]. Nihon Geka Gakkai Zasshi. 1991 Sep;92(9):1208-11. Japanese. PubMed PMID: 1944188.

2: Satoh T, Inatomi N, Satoh H, Marui S, Itoh Z, Omura S. EM-523, an erythromycin derivative, and motilin show similar contractile activity in isolated rabbit intestine. J Pharmacol Exp Ther. 1990 Sep;254(3):940-4. PubMed PMID: 2395122.

3: Depoortere I, Peeters TL, Vantrappen G. The erythromycin derivative EM-523 is a potent motilin agonist in man and in rabbit. Peptides. 1990 May-Jun;11(3):515-9. PubMed PMID: 2381873.

4: Inatomi N, Satoh H, Maki Y, Hashimoto N, Itoh Z, Omura S. An erythromycin derivative, EM-523, induces motilin-like gastrointestinal motility in dogs. J Pharmacol Exp Ther. 1989 Nov;251(2):707-12. PubMed PMID: 2810120.