E5700

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 531771

CAS#: 750597-23-0

Description: E5700 is a novel orally active squalene synthase inhibitor.


Price and Availability

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E5700 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 531771
Name: E5700
CAS#: 750597-23-0
Chemical Formula: C26H31N3O3
Exact Mass: 433.2365
Molecular Weight: 433.55
Elemental Analysis: C, 72.03; H, 7.21; N, 9.69; O, 11.07


Synonym: E5700; E 5700; E-5700.

IUPAC/Chemical Name: (3S)-3-(2-{2-benzyl-6-[(3S,4R)-3-hydroxy-4-methoxypyrrolidin-1-yl]pyridin-3-yl}ethynyl)-1-azabicyclo[2.2.2]octan-3-ol

InChi Key: NDEOTZXSBKCQLS-GSLIJJQTSA-N

InChi Code: InChI=1S/C26H31N3O3/c1-32-24-17-29(16-23(24)30)25-8-7-20(22(27-25)15-19-5-3-2-4-6-19)9-12-26(31)18-28-13-10-21(26)11-14-28/h2-8,21,23-24,30-31H,10-11,13-18H2,1H3/t23-,24+,26-/m0/s1

SMILES Code: O[C@@]1(C#CC2=CC=C(N3C[C@H](O)[C@H](OC)C3)N=C2CC4=CC=CC=C4)CN5CCC1CC5


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Ishida K, Visbal G, Rodrigues JC, Urbina JA, de Souza W, Rozental S. Two squalene synthase inhibitors, E5700 and ER-119884, interfere with cellular proliferation and induce ultrastructural and lipid profile alterations in a Candida tropicalis strain resistant to fluconazole, itraconazole, and amphotericin B. J Infect Chemother. 2011 Aug;17(4):563-70. doi: 10.1007/s10156-010-0190-1. PubMed PMID: 21264486.

2: Fernandes Rodrigues JC, Concepcion JL, Rodrigues C, Caldera A, Urbina JA, de Souza W. In vitro activities of ER-119884 and E5700, two potent squalene synthase inhibitors, against Leishmania amazonensis: antiproliferative, biochemical, and ultrastructural effects. Antimicrob Agents Chemother. 2008 Nov;52(11):4098-114. doi: 10.1128/AAC.01616-07. PubMed PMID: 18765694; PubMed Central PMCID: PMC2573141.

3: Urbina JA, Concepcion JL, Caldera A, Payares G, Sanoja C, Otomo T, Hiyoshi H. In vitro and in vivo activities of E5700 and ER-119884, two novel orally active squalene synthase inhibitors, against Trypanosoma cruzi. Antimicrob Agents Chemother. 2004 Jul;48(7):2379-87. PubMed PMID: 15215084; PubMed Central PMCID: PMC434216.