Valibose

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 527605

CAS#: 83470-79-5

Description: Valibose An α-glucosidase inhibitor potentially for the treatment of diabetes. Valibose significantly decreased postprandial and fasting blood glucose, urine glucose, and reduced the levels of serum fructosamine. Valibose also decreased plasma triglyceride and cholesterol levels. Valibose ameliorated metabolic disturbance of glucose and lipids. In addition, valibose markedly reduced level of serum NAG and BUN, and decreased the weight index of kidney.


Price and Availability

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Valibose is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 527605
Name: Valibose
CAS#: 83470-79-5
Chemical Formula: C10H21NO6
Exact Mass: 251.1369
Molecular Weight: 251.279
Elemental Analysis: C, 47.80; H, 8.42; N, 5.57; O, 38.20


Synonym: Valibose

IUPAC/Chemical Name: (1R,2S,3S,4S,6R)-4-((1,3-dihydroxypropan-2-yl)amino)-6-(hydroxymethyl)cyclohexane-1,2,3-triol

InChi Key: LWJUMCBIHCZWBT-JTBFQXKRSA-N

InChi Code: InChI=1S/C10H21NO6/c12-2-5-1-7(11-6(3-13)4-14)9(16)10(17)8(5)15/h5-17H,1-4H2/t5-,7+,8-,9+,10+/m1/s1

SMILES Code: O[C@H]1[C@@H](NC(CO)CO)C[C@H](CO)[C@@H](O)[C@@H]1O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Liu Q, Liu SN, Sun SJ, Shen ZF. [Valibose, an alpha-glucosidase inhibitor, ameliorates the metabolic disorder of glucose and lipids and the nephropathy in streptozotocin-induced diabetic rats]. Yao Xue Xue Bao. 2013 Aug;48(8):1227-32. Chinese. PubMed PMID: 24187828.

2: Zhong S, Zhong D, Chen X. Improved and simplified liquid chromatography/electrospray ionization mass spectrometry method for the analysis of underivatized glucosamine in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Jul 1;854(1-2):291-8. PubMed PMID: 17544344.

3: Dai XM, An N, Wu JM, Li HY, Zhang QM. Development and validation of HPLC-UV-MS method for the control of four anti-diabetic drugs in suspected counterfeit products. Yao Xue Xue Bao. 2010 Mar;45(3):347-52. PubMed PMID: 21348424.