F-901318

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 527521

CAS#: 1928707-56-5

Description: F-901318, also known as Olorofim, is a DHODH inhibitor potentially for the treatment of invasive aspergillosis. F-901318 demonstrates excellent potency against a broad range of dimorphic and filamentous fungi.


Price and Availability

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F-901318 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 527521
Name: F-901318
CAS#: 1928707-56-5
Chemical Formula: C28H27FN6O2
Exact Mass: 498.218
Molecular Weight: 498.5624
Elemental Analysis: C, 67.46; H, 5.46; F, 3.81; N, 16.86; O, 6.42


Synonym: F-901318; F901318; F 901318; Olorofim

IUPAC/Chemical Name: 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide

InChi Key: SUFPWYYDCOKDLL-UHFFFAOYSA-N

InChi Code: InChI=1S/C28H27FN6O2/c1-19-16-24(20-6-4-3-5-7-20)25(33(19)2)26(36)27(37)32-22-8-10-23(11-9-22)34-12-14-35(15-13-34)28-30-17-21(29)18-31-28/h3-11,16-18H,12-15H2,1-2H3,(H,32,37)

SMILES Code: O=C(NC1=CC=C(N2CCN(C3=NC=C(F)C=N3)CC2)C=C1)C(C4=C(C5=CC=CC=C5)C=C(C)N4C)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Oliver JD, Sibley GE, Beckmann N, Dobb KS, Slater MJ, McEntee L, du Pré S, Livermore J, Bromley MJ, Wiederhold NP, Hope WW, Kennedy AJ, Law D, Birch M. F901318 represents a novel class of antifungal drug that inhibits dihydroorotate dehydrogenase. Proc Natl Acad Sci U S A. 2016 Oct 25. pii: 201608304. [Epub ahead of print] PubMed PMID: 27791100; PubMed Central PMCID: PMC5111691.

2: Seyedmousavi S, Rafati H, Ilkit M, Tolooe A, Hedayati MT, Verweij P. Systemic Antifungal Agents: Current Status and Projected Future Developments. Methods Mol Biol. 2017;1508:107-139. PubMed PMID: 27837500.

3: Osherov N, Kontoyiannis DP. The anti-Aspergillus drug pipeline: Is the glass half full or empty? Med Mycol. 2017 Jan 1;55(1):118-124. PubMed PMID: 27562862.