Besigliptin Tosylate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 529407

CAS#: 1177460-72-8 (Besigliptin tosylate)

Description: Besigliptin Tosylate is a DPP-4 inhibitor potentially for the treatment of type 2 diabetes.


Price and Availability

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Besigliptin Tosylate is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 529407
Name: Besigliptin Tosylate
CAS#: 1177460-72-8 (Besigliptin tosylate)
Chemical Formula: C25H36FN5O5S
Exact Mass:
Molecular Weight: 537.6514
Elemental Analysis: C, 55.85; H, 6.75; F, 3.53; N, 13.03; O, 14.88; S, 5.96


Related CAS #: 1177459-85-6 (Besigliptin free base )  

Synonym: SHR-117887; SHR117887; SHR 117887

IUPAC/Chemical Name: (3aR,6aS)-5-((2-((2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl)-2-oxoethyl)amino)-N,N,5-trimethylhexahydrocyclopenta[c]pyrrole-2(1H)-carboxamide 4-methylbenzenesulfonate

InChi Key: VBMNNLBIPDGFBS-OFQXCICXSA-N

InChi Code: InChI=1S/C18H28FN5O2.C7H8O3S/c1-18(21-8-16(25)24-11-14(19)4-15(24)7-20)5-12-9-23(10-13(12)6-18)17(26)22(2)3;1-6-2-4-7(5-3-6)11(8,9)10/h12-15,21H,4-6,8-11H2,1-3H3;2-5H,1H3,(H,8,9,10)/t12-,13+,14-,15-,18?;/m0./s1

SMILES Code: O=C(N1C[C@@]2([H])[C@@](CC(C)(NCC(N3[C@H](C#N)C[C@H](F)C3)=O)C2)([H])C1)N(C)C.O=S(C4=CC=C(C)C=C4)(O)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Liu X, Zhang LN, Feng Y, Zhang L, Qu H, Cao GQ, Leng Y. Acute and chronic
administration of SHR117887, a novel and specific dipeptidyl peptidase-4
inhibitor, improves metabolic control in diabetic rodent models. Acta Pharmacol
Sin. 2012 Aug;33(8):1013-22. doi: 10.1038/aps.2012.75. PubMed PMID: 22842733;
PubMed Central PMCID: PMC4011329.