BF738735

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530500

CAS#: 1436383-95-7

Description: BF738735 is a potent and selective PI4KIIIβ Inhibitor. BF738735 displays antiviral property. BF738735 targets OSBP and inhibit cholesterol shuttling to replication organelles.


Price and Availability

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BF738735 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 530500
Name: BF738735
CAS#: 1436383-95-7
Chemical Formula: C21H19FN4O3S
Exact Mass: 426.1162
Molecular Weight: 426.4664
Elemental Analysis: C, 59.14; H, 4.49; F, 4.45; N, 13.14; O, 11.25; S, 7.52


Synonym: BF738735; BF-738735; BF 738735.

IUPAC/Chemical Name: 2-fluoro-4-(2-methyl-8-((3-(methylsulfonyl)benzyl)amino)imidazo[1,2-a]pyrazin-3-yl)phenol

InChi Key: IMHZCCZYPHJVMS-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H19FN4O3S/c1-13-19(15-6-7-18(27)17(22)11-15)26-9-8-23-20(21(26)25-13)24-12-14-4-3-5-16(10-14)30(2,28)29/h3-11,27H,12H2,1-2H3,(H,23,24)

SMILES Code: OC1=CC=C(C=C1F)C2=C(C)N=C3C(NCC4=CC=CC(S(=O)(C)=O)=C4)=NC=CN32


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1. van der Schaar, Hilde M.; Leyssen, Pieter; Thibaut, Hendrik J.; de Palma, Armando; van der Linden, Lonneke; Lanke, Kjerstin H. W.; Lacroix, Celine; Verbeken, Erik; Conrath, Katja; MacLeod, Angus M.; et al A novel, broad-​spectrum inhibitor of enterovirus replication that targets host cell factor phosphatidylinositol 4-​kinase IIIβ. Antimicrobial Agents and Chemotherapy (2013), 57(10), 4971-4981.

2. MacLeod, Angus M.; Mitchell, Dale R.; Palmer, Nicholas J.; Van de Poel, Herve; Conrath, Katja; Andrews, Martin; Leyssen, Pieter; Neyts, Johan Identification of a Series of Compounds with Potent Antiviral Activity for the Treatment of Enterovirus Infections. ACS Medicinal Chemistry Letters (2013), 4(7), 585-589.