BMS753
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 531559

CAS#: 215307-86-1

Description: BMS753 is a RARα-selective agonist (Ki = 2 nM). It regulates the ATRA-inducible cytochrome P450 26A1 (CYP26A1).

Chemical Structure

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BMS753
CAS# 215307-86-1
Instruction

Theoretical Analysis

MedKoo Cat#: 531559
Name: BMS753
CAS#: 215307-86-1
Chemical Formula: C21H21NO4
Exact Mass: 351.15
Molecular Weight: 351.400
Elemental Analysis: C, 71.78; H, 6.02; N, 3.99; O, 18.21

Price and Availability

Size Price Availability Quantity
5mg USD 280 2 weeks
10mg USD 450 2 weeks
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Synonym: BMS753; BMS 753; BMS-753.

IUPAC/Chemical Name: 4-[(1,1,3,3-tetramethyl-2-oxoindene-5-carbonyl)amino]benzoic acid

InChi Key: KFBPBWUZXBYJDG-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H21NO4/c1-20(2)15-10-7-13(11-16(15)21(3,4)19(20)26)17(23)22-14-8-5-12(6-9-14)18(24)25/h5-11H,1-4H3,(H,22,23)(H,24,25)

SMILES Code: O=C(O)C1=CC=C(NC(C2=CC3=C(C(C)(C)C(C3(C)C)=O)C=C2)=O)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 351.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Idres N, Marill J, Chabot GG. Regulation of CYP26A1 expression by selective RAR and RXR agonists in human NB4 promyelocytic leukemia cells. Biochem Pharmacol. 2005 Jun 1;69(11):1595-601. PubMed PMID: 15896339.